Cleveland Clinic Orthopaedic Research Training Grant

描述(由申请人提供)： 克利夫兰临床基金会(CCF)整形外科研究中心计划进行协调一致的培训工作，为此，我们要求两名博士后和两名博士后科学家，一名临床科学家，以及三名12周研究经验的医学生在一年级。来自生物医学工程和整形外科系的研究人员和临床医生/科学家已经在三个广泛的领域积极合作：(1)骨生物学和生物力学，(2)软组织生物学和生物力学，(3)关节和全身生物力学。这些高度互动的领域为从细胞/分子生物学技术到体内或体外模型和临床研究项目的教学和实验台级别的培训提供了大量机会。招聘计划包括激励实习后的临床医生兼科学家参与一系列丰富的临床-基础科学合作伙伴关系。我们概述了确保这些培训机会取得成功所需的预计组织和行政结构。除了这三个专题领域中每一个领域的重点活动外，还计划开展一系列综合活动，以巩固CCF在骨科科学方面的既定教育和培训记录。其中包括40个讲座的基础科学课程，两个系列研讨会，生物伦理学和生物统计学讲座，赠款准备讲习班，发明学论坛，教学机会，以及向专业会议提交强制性摘要。将为项目主任和导师的工资、书籍和期刊以及临床医生-科学家的工资补充提供机构支持。这项提案中概述的目标与该机构鼓励临床和转化性研究的努力紧密一致，该中心于2003年初获得批准，并在凯斯西储大学新建的克利夫兰临床勒纳医学院开展临床和转化性研究，这是一个以研究为基础的5年制项目，将于2004年招收第一批学生。

DESCRIPTION(Provided by Applicant): The Orthopaedic Research Center of The Cleveland Clinic Foundation (CCF) plans a coordinated, training effort for which we request 2 pre-doctoral and 2 post-doctoral scientists, one clinician scientist, and three 12 week research experiences for medical students in Year 1. Investigators and clinician/scientists from the Departments of Biomedical Engineering and Orthopaedic Surgery are already actively collaborating in 3 broad areas: (1) bone biology and biomechanics, (2) soft tissue biology and biomechanics, (3) joint and whole-body biomechanics. These highly interactive areas offer substantial opportunities for didactic and bench-level training in areas ranging from cell/molecular biological techniques to in vivo or in vitro models and clinical research projects. Recruitment plans include incentives for a post-residency clinician-scientist to participate in one of a rich array of clinical-basic science partnerships. We outline the projected organizational and administrative structures necessary to ensure the success of these training opportunities. In addition to focused activities in each of the three topic areas, a range of integrative activities are planned to build upon an established record of education and training in the orthopaedic sciences at CCF. These include a 40-lecture basic science curriculum, two seminar series, bioethics and biostatistics lectures, grant preparation workshops, inventorship forums, teaching opportunities, and mandatory abstract submission to professional meetings. Institutional support will be provided for the salaries of the program directors and mentors, and for books and journals and for salary supplementation for the clinician-scientist. The goals outlined in this proposal align closely with the institution's efforts to encourage clinical and translational research in a General Clinical Research Center (approved in early 2003) and in the new Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, a research-based, 5-year program that will admit its first class in 2004.