CVD ZIRCONIA COATING ON ORTHOPEDIC IMPLANTS

骨科植入物上的 CVD 氧化锆涂层

• 批准号: 2081123
• 负责人: PIRAN SIOSHANSI
• 金额: $ 32.49万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-25 至 1997-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2081123
• 关键词: X ray crystallography; adhesions; alloys; biomaterial compatibility; biomaterial development /preparation; biomedical equipment development; ceramics; chromium; cobalt; hip prosthesis; implant; laboratory rabbit; molecular film; molybdenum; tissue /cell culture; zirconium

The goal of Phase II is to further establish the safety and efficacy of depositing a zirconia coating on cobalt-chromium (Co-Cr) alloy orthopaedic components to substantially decrease wear of the mating polyethylene part. More than 350,000 total knee and total hip replacements are presently performed in the U.S. each year. In several recent review articles, 1-4 UHMWPE wear debris and the accompanying granuloma formation were identified as the primary complications in long range joint replacement survival. UHMWPE wear in total hip arthroplasty is estimated to be typically as high as 200 micrometers per year. During Phase I, the effects of a zirconia coating on Co-Cr devices to reduce wear to the mating UHMWPE part were investigated. Mechanical wear tests (one million reciprocating cycles) showed that UHMWPE disks articulated against the zirconia coated Co-Cr canine femur heads wore 70% less than UHMWPE articulated against non-coated Co-Cr. Analysis showed that zirconia coated Co-Cr is significantly more lubricious and harder than the untreated metal. Phase II will continue to refine zirconia coatings on Co-Cr using a number of tests including a 10,000,000-cycle joint simulation study. PROPOSED COMMERCIAL APPLICATION: A method for improving wear resistance in UHMWPE is urgently needed; manufacturers and orthopaedic surgeons are keenly interested in minimizing UHMWPE wear. Major orthopaedic manufacturers with whom we have a close working relationship have expressed interest in commercializing the process once joint simulator test results become available. The market for zirconia coating of Co-Cr components is therefore significant.

第二阶段的目标是进一步确定的安全性和有效性 在钴-铬（Co-Cr）合金矫形外科上沉积氧化锆涂层 组件，以大大减少匹配的聚乙烯部件的磨损。 目前有超过350，000例全膝关节和全髋关节置换术 每年在美国举行。 在最近的几篇综述文章中，1-4 UHMWPE磨损碎屑和伴随的肉芽肿形成是 确定为长距离关节置换术的主要并发症 生存 全髋关节置换术中的UHMWPE磨损估计为 通常高达每年200微米。 在第一阶段，氧化锆涂层对钴铬合金器械的影响， 减少对匹配UHMWPE部件的磨损。 机械磨损 试验（100万次往复循环）表明， 与氧化锆涂层Co-Cr犬股骨头关节连接，磨损70% 小于UHMWPE与无涂层Co-Cr的关节面。 分析表明 氧化锆涂层的钴铬合金明显更光滑， 比未经处理的金属。 二期将继续提炼氧化锆 涂层上的钴铬使用了大量的测试，包括1000万次循环， 联合模拟研究。 拟议的商业应用：一种提高耐磨性的方法 制造商和整形外科医生， 对尽量减少UHMWPE磨损非常感兴趣。 大型矫形 与我们有密切合作关系的制造商 表示有兴趣商业化的过程，一旦联合模拟器 测试结果可用。 钴铬氧化锆涂层市场 因此，组件非常重要。