CVD ZIRCONIA COATING ON ORTHOPEDIC IMPLANTS

第二阶段的目标是进一步确定 矫形外科钴铬(Co-Cr)合金表面氧化锆涂层的制备 组件，以大大减少匹配的聚乙烯部件的磨损。 目前有超过35万例全膝关节和全髋关节置换术 每年都会在美国演出。在最近的几篇评论文章中，1-4 UHMWPE磨屑和随之而来的肉芽肿形成 远距离关节置换术的主要并发症 生死存亡。全髋关节置换术中超高相对分子质量聚乙烯的磨损估计为 通常每年高达200微米。 在第一阶段，在钴铬器件上涂覆氧化锆层的效果 研究了降低UHMWPE配合件磨损的方法。机械磨损 试验(100万次往复循环)表明，UHMWPE圆盘 铰接式氧化锆涂层钴铬犬股骨头磨损率为70% 低于UHMWPE，与未涂覆的钴铬连接。分析表明， 氧化锆包覆的钴铬合金明显更有光泽和硬度 而不是未经处理的金属。第二阶段将继续提炼氧化锆矿 使用包括1000万次循环在内的多项试验在钴铬上获得涂层 联合仿真研究。 拟议的商业应用：一种提高耐磨性的方法 在UHMWPE中急需；制造商和整形外科医生 对最大限度地减少UHMWPE磨损非常感兴趣。专业骨科 与我们有密切工作关系的制造商 表示有兴趣将工艺一旦联合模拟器商业化 测试结果将可用。钴铬氧化锆涂层的市场 因此，组件具有重要意义。

The goal of Phase II is to further establish the safety and efficacy of depositing a zirconia coating on cobalt-chromium (Co-Cr) alloy orthopaedic components to substantially decrease wear of the mating polyethylene part. More than 350,000 total knee and total hip replacements are presently performed in the U.S. each year. In several recent review articles, 1-4 UHMWPE wear debris and the accompanying granuloma formation were identified as the primary complications in long range joint replacement survival. UHMWPE wear in total hip arthroplasty is estimated to be typically as high as 200 micrometers per year. During Phase I, the effects of a zirconia coating on Co-Cr devices to reduce wear to the mating UHMWPE part were investigated. Mechanical wear tests (one million reciprocating cycles) showed that UHMWPE disks articulated against the zirconia coated Co-Cr canine femur heads wore 70% less than UHMWPE articulated against non-coated Co-Cr. Analysis showed that zirconia coated Co-Cr is significantly more lubricious and harder than the untreated metal. Phase II will continue to refine zirconia coatings on Co-Cr using a number of tests including a 10,000,000-cycle joint simulation study. PROPOSED COMMERCIAL APPLICATION: A method for improving wear resistance in UHMWPE is urgently needed; manufacturers and orthopaedic surgeons are keenly interested in minimizing UHMWPE wear. Major orthopaedic manufacturers with whom we have a close working relationship have expressed interest in commercializing the process once joint simulator test results become available. The market for zirconia coating of Co-Cr components is therefore significant.