ADVANCED SPIRAL CUFF ELECTRODE FABRICATION

描述（改编自申请人的摘要）：该计划 目的是开发一种快速、可靠和可重复的 螺旋箍神经电极的制造方法， 用于恢复神经受损个体的功能。 等 目前的设备是手工制造的， 将铂箔切割并粘合到硅橡胶上的方法 衬底和使用硬线进行互连。这项建议 解决了薄膜沉积技术的进一步发展， 在硅橡胶上形成图案化的金属层， 需要手工制作，大大提高了工艺产量， 产品可靠性。薄的可行性和原理证明 在第一阶段建立了电影方法。一种快速廉价的方法 使用个人计算机和激光打印机开发图案化。 然后使用离子束辅助沉积（IBID）来存款极 以适当的图案粘附金属层。使用 已建立的拉伸硅胶片层压技术，导电 制造了具有理想卷曲和柔性的电极。 相 II将优化薄膜沉积条件，进一步提高薄膜 延展性和导电性，并使引线宽度最小化。问题周围 电极的大规模生产，特别是在金属后处理中， 将解决制造工艺的沉积部分。 动物研究将用于评价药物的重要性质。 设备，如阈值功率水平，分级的力量，短和 募集性质的长期稳定性和生物相容性。 该评价将在多个中心进行， 电极设计。

DESCRIPTION (Adapted from the applicant's abstract): The program objective is development of a rapid, reliable, and reproducible manufacturing process for fabrication of spiral cuff nerve electrodes, used to restore function in neurologically impaired individuals. Such devices are currently fabricated by hand in a laborious, unreliable process by cutting and gluing platinum foils to silicone rubber substrates and using hard wires for interconnects. This proposal addresses further development of thin film deposition technology to create patterned metallic layers on the silicone rubber, eliminating the need for hand construction and vastly increasing process yield and product reliability. The feasibility and proof-of-principle of the thin film approach were established in Phase I. A rapid, inexpensive method of patterning was developed using a personal computer and laser printer. Ion beam assisted deposition (IBID) was then used to deposit extremely adherent metallic layers in the appropriate pattern. Using the established stretched silicone sheet lamination technique, conductive electrodes with ideal curling and flexibility were fabricated. Phase II will optimize thin film deposition conditions to further improve film ductility and conductivity and minimize lead width. Issues surrounding mass production of the electrodes, particularly in the post-metal deposition portions of the fabrication process, will be addressed. Animal studies will be used to evaluate important properties of the devices, such as threshold power levels, grading of force, short and long-term stability of recruitment properties, and biocompatibility. This evaluation will take place at multiple centers and with various electrode designs.