MEIOTIC GENETICS IN D DISCOIDEUM

盘状 D 的减数分裂遗传学

• 批准号: 2744635
• 负责人: RICHARD Harry KESSIN
• 金额: $ 11.9万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2744635
• 关键词: Dictyostelium; cytogenetics; genetic mapping; genetic recombination; genetic strain; meiosis; microorganism genetics; microorganism reproduction

The single aim is to develop a system of meiotic genetic analysis for Dictyostelium discoideum. Dictyostelium has served as a model system for studying single cell amoeboid motility and chemotaxis and multi- cellular fate selection and regulation. The major limitation has been the difficulty in genetic analysis of this haploid organism. Dictyostelium has enjoyed a resurgence in recent years due the ease of homologous gene replacement to study a variety of cellular functions. In the wild, Dictyostelium has a sexual, diploid cycle. Unfortunately, the laboratory strains of Dictyostelium have lost this ability. Kessin proposes methods to establish sexual strains of Dictyostelium which will be essential for genetic mapping, isogenization of strains, and creating multiple mutant stocks.

唯一的目的是发展一个系统的减数分裂遗传分析