A strain respository for Dictyostelium discoideum

盘基网柄菌菌株保藏库

• 批准号: 6646446
• 负责人: RICHARD Harry KESSIN
• 金额: $ 32.61万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6646446
• 关键词: Dictyostelium; genetic strain; microorganism genetics; microorganism resource /registry; molecular biology information system; molecular genetics; preservation

DESCRIPTION (provided by applicant):The social amoeba Dictyostelium is an experimental organism with an expanding repertoire of genetic techniques. In addition to the experimental advantages that it offers, this amoeba is being used to address questions in numerous areas of biology that range from bacterial pathogenesis to chemotaxis and motility, to evolutionary biology, among many others. The workers in the field are generating a large number of strains and other valuable tools, including many cDNA and mutant libraries. Research using Dictyostelium would be made more effective if these strains and libraries could be stored safely and distributed effectively. Therefore, we propose to establish a strain repository to secure, test, and distribute the raw material for research in this field. The curators of this facility would also maintain the database of Dictyostelium references, now numbering more than 7000, and provide other assistance to people who wish to exploit Dictyostelium to answer a variety of biological questions. We envisage a very active facility serving the community.

描述（由申请人提供）：社会阿米巴Dictyosteoba是一种实验生物，具有不断扩大的遗传技术库。除了它所提供的实验优势外，这种阿米巴还被用于解决许多生物学领域的问题，从细菌发病机制到趋化性和运动性，再到进化生物学等等。该领域的工作人员正在产生大量的菌株和其他有价值的工具，包括许多cDNA和突变体文库。如果这些菌株和文库能够安全地储存并有效地分发，使用网囊藻的研究将更加有效。因此，我们建议建立一个菌株储存库，以确保，测试和分发该领域研究的原材料。该设施的管理者还将维护网骨藻参考文献的数据库，目前已有7000多个，并为希望利用网骨藻回答各种生物学问题的人提供其他帮助。我们设想一个非常活跃的设施，为社区服务。