ALKYNYLIODONIUM CHEMISTRY IN ORGANIC SYNTHESIS
ALKYNYLIODONIUM CHEMISTRY IN ORGANIC SYNTHESIS
批准号:
6018678
负责人:
KEN S. FELDMAN
金额:
$20.24万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-01-01 至 2000-06-30
中文摘要
炔基碘鎓盐的开发与应用
将进行立体选择性有机合成。 这些试剂
显示出独特的反应模式,
结构容易从简单的无环前体组装。 在
特别地,含氮粘合剂与这些盐的使用将
导致几个分子框架的有效构建,
药学上感兴趣的生物碱,包括
三尖杉属植物群,以及弹力蛋白A、麦哲伦酮和
帕劳胺。 这些目标结构中的几个(例如,
脱氧三尖杉酯碱,agelastatin A)显示非常有前途的抗白血病
和抗氧化活性,
免疫调节反应。 及时获取这些生物活性靶标
通过炔基碘鎓盐方法将有助于
了解它们的作用机制,并将提供
用于进一步优化/评价生物活性的结构。
英文摘要
The development and exploitation of alkynyliodonium salts for
stereoselective organic synthesis will be pursued. These reagents
display unique reactivity patterns which permit polycyclic chemical
structures to be assembled readily from simple acyclic precursors. In
particular, the use of nitrogen-containing addends with these salts will
lead to efficient construction of the molecular framework of several
pharmaceutically interesting alkaloids including members of the
Cephalotaxus group, as well as agelastatin A, magellaninone, and
palau'amine. Several of these target structures (e.g.,
deoxyharringtonine, agelastatin A) display very promising antileukemic
and antineoplastic activity, while palau'amine elicits an
immunomodulatory response. Timely acquisition of these bioactive targets
through alkynyliodonium salt methodology will contribute to an
understanding of their mechanism of action and will provide lead
structures for further optimization/evaluation of biological activity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7909518
-
项目类别:
-
资助金额:$15.07万
-
财政年份:2009
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7920746
-
项目类别:
-
资助金额:$2.79万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:6849382
-
项目类别:
-
资助金额:$26.62万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7344793
-
项目类别:
-
资助金额:$22.58万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:8020522
-
项目类别:
-
资助金额:$2.13万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7582248
-
项目类别:
-
资助金额:$22.57万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:8119361
-
项目类别:
-
资助金额:$7.72万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7179302
-
项目类别:
-
资助金额:$22.58万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL-MEDIATED FIVE MEMBERED RING SYNTHESIS
-
批准号:3293204
-
项目类别:
-
资助金额:$11.61万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7046950
-
项目类别:
-
资助金额:$23.69万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
-
批准号:6385661
-
项目类别:
-
资助金额:$22.32万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL MEDIATED CYCLIZATION REACTIONS
-
批准号:3293202
-
项目类别:
-
资助金额:$16.99万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL-MEDIATED FIVE MEMBERED RING SYNTHESIS
-
批准号:3293197
-
项目类别:
-
资助金额:$12.53万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
-
批准号:6191446
-
项目类别:
-
资助金额:$22.33万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
-
批准号:6519244
-
项目类别:
-
资助金额:$22.32万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
-
批准号:6925174
-
项目类别:
-
资助金额:$7.68万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7388174
-
项目类别:
-
资助金额:$23.26万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7209774
-
项目类别:
-
资助金额:$23.27万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM CHEMISTRY IN ORGANIC SYNTHESIS
-
批准号:2444641
-
项目类别:
-
资助金额:$18.71万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL MEDIATED CYCLIZATION REACTIONS
-
批准号:3293205
-
项目类别:
-
资助金额:$15.28万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
海外基金