ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
批准号:
6191446
负责人:
KEN S. FELDMAN
金额:
$22.33万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-01-01 至 2004-06-30
中文摘要
描述:(逐字摘自申请人摘要)持续的
炔基碘鎓盐介导的碳环化的发展和
杂环化反应,以及该化学在总反应中的应用
计划合成具有治疗前景的天然产物。一个简洁的
从防己科植物中合成有效的抗白血病原理,
帕瑞托酮,将被启动。此外,合成程序指导
结构新颖的 VCAM-1 诱导抑制剂 halichlorine 将
开始。亲核引发的新级联环化的发现
除了具有适当位置的不饱和的炔基碘盐之外
功能将构成拟议研究的中心主旨。这些
多步转换将导致各种高效组装
常见的多环系统,包括二奎烷,
前卡内烷、α-亚甲基环戊酮、环戊烷苯并呋喃、
和环戊烷吲哚。在一个单独的脉络中,一代和
甲硅烷氧基亚烷基卡宾的高效碳环化反应将是
调查了。这些发展研究将取得有希望的进展
然后将该方法应用于同源化合物的合成
目标。总而言之,这些研究将引入新的、简洁的
多环有机小分子的制备技术
通常寻求作为药物先导化合物的类型。
英文摘要
Description: (Verbatim from the Applicant's Abstract) The continuing
development of alkynyliodonium salt-mediated carbocyclization and
heterocyclization reactions, and application of this chemistry to the total
synthesis of therapeutically promising natural products, is planned. A concise
synthesis of the potent antileukemic principle from Menispermaceae,
pareitropone, will be initiated. In addition, a synthesis program directed
toward the structurally novel VCAM-1 induction inhibitor halichlorine will
commence. The discovery of new cascade cyclizations triggered by nucleophilic
addition to alkynyliodonium salts bearing appropriately positioned unsaturated
functionality will constitute a central thrust of the proposed research. These
multi-step transformations will lead to efficient assembly of a variety of
commonly encountered polycyclic ring systems, including diquinanes,
precapnellanes, alpha-methylenecyclopentanones, cyclopentannelated benzofurans,
and cyclopentannelated indoles. In a separate vein, the generation and
productive carbocyclization of silyloxyalkylidene carbenes will be
investigated. Promising advances in these developmental studies will be
followed by application of the methodology toward the synthesis of cognate
targets. Taken together, these studies will introduce new and concise
techniques for preparing small polycyclic organic molecules of the
type typically sought as pharmaceutical leads.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7909518
-
项目类别:
-
资助金额:$15.07万
-
财政年份:2009
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7920746
-
项目类别:
-
资助金额:$2.79万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:6849382
-
项目类别:
-
资助金额:$26.62万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7344793
-
项目类别:
-
资助金额:$22.58万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:8020522
-
项目类别:
-
资助金额:$2.13万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7582248
-
项目类别:
-
资助金额:$22.57万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:8119361
-
项目类别:
-
资助金额:$7.72万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
New Methodology for Indole Alkaloid Syntheses
-
批准号:7179302
-
项目类别:
-
资助金额:$22.58万
-
财政年份:2006
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL-MEDIATED FIVE MEMBERED RING SYNTHESIS
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批准号:3293204
-
项目类别:
-
资助金额:$11.61万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7046950
-
项目类别:
-
资助金额:$23.69万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
-
批准号:6385661
-
项目类别:
-
资助金额:$22.32万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM CHEMISTRY IN ORGANIC SYNTHESIS
-
批准号:6018678
-
项目类别:
-
资助金额:$20.24万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL MEDIATED CYCLIZATION REACTIONS
-
批准号:3293202
-
项目类别:
-
资助金额:$16.99万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL-MEDIATED FIVE MEMBERED RING SYNTHESIS
-
批准号:3293197
-
项目类别:
-
资助金额:$12.53万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
-
批准号:6519244
-
项目类别:
-
资助金额:$22.32万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM SALTS IN ORGANIC SYNTHESIS
-
批准号:6925174
-
项目类别:
-
资助金额:$7.68万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7388174
-
项目类别:
-
资助金额:$23.26万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
Alkynyliodonium Salts and Derived Diyls in Synthesis
-
批准号:7209774
-
项目类别:
-
资助金额:$23.27万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
ALKYNYLIODONIUM CHEMISTRY IN ORGANIC SYNTHESIS
-
批准号:2444641
-
项目类别:
-
资助金额:$18.71万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
RADICAL MEDIATED CYCLIZATION REACTIONS
-
批准号:3293205
-
项目类别:
-
资助金额:$15.28万
-
财政年份:1987
-
负责人:KEN S. FELDMAN
-
依托单位:
海外基金