PREGNANCY AND EXERCISE

怀孕和运动

• 批准号: 2838736
• 负责人: JAMES F CLAPP
• 金额: $ 23.72万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2838736
• 关键词: bioenergetics; blood chemistry; calorimetry; child physical development; clinical research; dietary carbohydrates; disease /disorder prevention /control; embryo /fetus; exercise; female; human pregnant subject; human therapy evaluation; low birth weight infant human; morphology; nutrition related tag; outcomes research; placenta; pregnancy; pregnancy circulation; premature labor; ultrasonography

The long range goal of this proposal is to examine the interaction between regular exercise and the course and outcome of the pregnancy. Its specific aims are: to determine if regular exercise induces changes in maternal physiological function and placental growth and functional capacity and thereby improve fetal growth and pregnancy outcome in a variety of populaces, to assess the modulatory role of diet on these exercise effects, and to determine if the beneficial effects of exercise are regulated in part by decreasing the need for flow redistribution during cardiovascular stress. It will test 3 hypotheses. First, that beginning a program of regular exercise early in the second trimester will reduce the incidence of preterm birth and low birth weight in demographically at risk populaces. Second, that dietary carbohydrate mix modifies the impact of exercise on maternal weight gain, fat deposition, feto-placental growth and size at birth. Third, different threshold volumes of regular exercise are required to produce each specific beneficial effect. It is based on earlier studies which indicate that regular exercise during pregnancy has positive effects for both mother and fetus in two specific populaces of women. It will complete prospective, randomized training studies in two groups of women who are at low demographic risk and in two groups of women who are at high demographic risk for poor outcome. The techniques employed include: respiratory calorimetry and doubly labeled water for energy expenditure, ultrasound for measuring feto-placental growth, total body electrical conductivity and 18/O for body composition, along with other gross and histomorphometric techniques. The proposal should determine the preventive value of regular exercise in both low and high risk pregnancy and provide insight into several mechanisms which regulate its beneficial effects.

本提案的长期目标是研究 定期锻炼和过程和结果之间的 怀孕 其具体目标是：确定定期锻炼是否会导致 变化 在母体生理功能和胎盘生长方面， 功能 能力，从而改善胎儿生长和妊娠结局， 一 各种人群，以评估饮食对 这些 运动的影响，并确定是否有益的影响， 行使 部分是通过减少对流量的需求来调节的 再分配 在心血管压力下。 它将测试三个假设。 第一、 的 在第二天的早些时候开始一个有规律的锻炼计划， 孕 将减少早产和低出生体重的发生率， 在人口统计学上处于危险中的人群。 第二，饮食 碳水化合物混合 修改运动对母亲体重增加，脂肪 沉积， 出生时胎儿-胎盘的生长和大小。 三不同 阈值 需要大量的定期锻炼来产生每一个特定的 有益效果。 这是基于早期的研究表明， 的 怀孕期间经常锻炼对两者都有积极影响 母亲 和胎儿之间的关系。 它将完成 在两组女性中进行的前瞻性随机培训研究， 是 在低人口风险和两组妇女谁是高 不良结局的人口学风险。 采用的技术 包括以下步骤： 呼吸量热法和双标记水供能 支出， 胎儿-胎盘生长测量用全身超声 电 电导率和身体成分18/O，沿着其他总 和 组织形态计量学技术。 该提案应确定 定期运动对低危和高危人群的预防价值 妊娠 并提供了几种机制，调节其 有益 方面的影响.