ANIMAL MODELS OF HUMAN VIRAL INFECTIONS

这项研究的目的是利用流感的动物模型 病毒感染，它有几个类似于人类疾病的特征， 用于评估候选抗病毒药物的临床前潜力。 动物模型包括感染实验室小鼠，这些小鼠 已成功用于评价流感病毒抑制化合物 和生物反应调节剂(BRM)在现已终止的NIAID中 动物模型合同。该模型使用了几个参数来 测量疾病的严重程度。包括脉搏血氧仪的应用 目前广泛应用于临床日常血氧监测 饱和度。整个研究计划利用了病毒学的混合 对这种病毒的专业知识、化疗专业知识和免疫学专业知识 非常适合完成所需工作的背景。

The objective of this research is to utilize an animal model of influenza virus infection, which has several features similar to the human disease, for evaluating the preclinical potential of candidate antiviral agents. The animal model consists of an infection of laboratory mice which have been used successfully for evaluating influenza virus-inhibitory compounds and biological response modifiers (BRMs) in the now-terminating NIAID Animal Models contract. This model employs several parameters for measuring disease severity. including utilization of pulse oximetry currently widely used in the clinic for monitoring daily blood oxygen saturation. The overall research plan utilizes a blend of virologic expertise with this virus, chemotherapeutic expertise, and immunologic backgrounds well suited to achieve the work required.