ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
批准号:
6365885
负责人:
Robert W. Sidwell
金额:
$12.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-11-30 至 2000-11-30
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The objective of this research is to utilize an animal model of influenza
virus infection, which has several features similar to the human disease,
for evaluating the preclinical potential of candidate antiviral agents.
The animal model consists of an infection of laboratory mice which have
been used successfully for evaluating influenza virus-inhibitory compounds
and biological response modifiers (BRMs) in the now-terminating NIAID
Animal Models contract. This model employs several parameters for
measuring disease severity. including utilization of pulse oximetry
currently widely used in the clinic for monitoring daily blood oxygen
saturation. The overall research plan utilizes a blend of virologic
expertise with this virus, chemotherapeutic expertise, and immunologic
backgrounds well suited to achieve the work required.
期刊论文(26)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin.
使用环戊烷神经氨酸酶抑制剂 RWJ-270201 和利巴韦林联合治疗细胞培养物和小鼠中的甲型流感病毒感染。
DOI:
10.1159/000057668
发表时间:
2002
期刊:
Chemotherapy
影响因子:
3.3
作者:
[Smee,DonaldF, Bailey,KevinW, Morrison,AnnC, Sidwell,RobertW]
通讯作者:
Sidwell,RobertW
Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice.
西多福韦和环 HPMPC 对小鼠致死性牛痘和牛痘病毒呼吸道感染的比较作用。
DOI:
10.1159/000070618
发表时间:
2003
期刊:
Chemotherapy
影响因子:
3.3
作者:
[Smee,DonaldF, Bailey,KevinW, Sidwell,RobertW]
通讯作者:
Sidwell,RobertW
Transgenic mice as a chemotherapeutic model for hepatitis B virus infection.
转基因小鼠作为乙型肝炎病毒感染的化疗模型。
DOI:
--
发表时间:
1998
期刊:
Antiviral therapy
影响因子:
1.2
作者:
[Morrey,JD, Korba,BE, Sidwell,RW]
通讯作者:
Sidwell,RW
Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201.
病毒株、攻击剂量和治疗开始时间对 RWJ-270201 体内流感抑制作用的影响。
DOI:
10.1016/s0166-3542(01)00149-8
发表时间:
2001
期刊:
Antiviral research
影响因子:
7.6
作者:
[Sidwell,RW, Smee,DF, Huffman,JH, Barnard,DL, Morrey,JD, Bailey,KW, Feng,WC, Babu,YS, Bush,K]
通讯作者:
Bush,K
Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine.
用奥司他韦、利巴韦林和韦拉米定治疗小鼠中甘露聚糖增强的乙型流感病毒感染。
DOI:
10.1177/095632020401500505
发表时间:
2004
期刊:
Antiviral chemistry & chemotherapy
影响因子:
--
作者:
[Smee,DonaldF, Wandersee,MilesK, Wong,Min-Hui, Bailey,KevinW, Sidwell,RobertW]
通讯作者:
Sidwell,RobertW
共 11 条
IN VITRO ANTIVIRAL SCREENS FOR RESPIRATORY VIRUSES
-
批准号:6395043
-
项目类别:
-
资助金额:$9.0万
-
财政年份:1998
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREENS FOR RESPIRATORY VIRUSES
-
批准号:2878209
-
项目类别:
-
资助金额:$24.59万
-
财政年份:1998
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREENS FOR RESPIRATORY VIRUSES
-
批准号:6359364
-
项目类别:
-
资助金额:$12.81万
-
财政年份:1998
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREENS FOR RESPIRATORY VIRUSES
-
批准号:6159641
-
项目类别:
-
资助金额:$38.19万
-
财政年份:1998
-
负责人:Robert W. Sidwell
-
依托单位:
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
-
批准号:6158926
-
项目类别:
-
资助金额:$8.97万
-
财政年份:1995
-
负责人:Robert W. Sidwell
-
依托单位:
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
-
批准号:2697391
-
项目类别:
-
资助金额:$28.29万
-
财政年份:1995
-
负责人:Robert W. Sidwell
-
依托单位:
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
-
批准号:2296607
-
项目类别:
-
资助金额:$5.82万
-
财政年份:1995
-
负责人:Robert W. Sidwell
-
依托单位:
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
-
批准号:2296608
-
项目类别:
-
资助金额:$22.15万
-
财政年份:1995
-
负责人:Robert W. Sidwell
-
依托单位:
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
-
批准号:6024307
-
项目类别:
-
资助金额:$29.29万
-
财政年份:1995
-
负责人:Robert W. Sidwell
-
依托单位:
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
-
批准号:2797835
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1995
-
负责人:Robert W. Sidwell
-
依托单位:
ANIMAL MODELS OF HUMAN VIRAL INFECTIONS
-
批准号:2296610
-
项目类别:
-
资助金额:$27.36万
-
财政年份:1995
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2295911
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2295912
-
项目类别:
-
资助金额:$15.23万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2295908
-
项目类别:
-
资助金额:$14.1万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2295909
-
项目类别:
-
资助金额:$14.65万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2295906
-
项目类别:
-
资助金额:$13.84万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2295907
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2489152
-
项目类别:
-
资助金额:$15.82万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
IN VITRO ANTIVIRAL SCREEN FOR RESPIRATORY VIRUSES
-
批准号:2662801
-
项目类别:
-
资助金额:$7.5万
-
财政年份:1993
-
负责人:Robert W. Sidwell
-
依托单位:
BIOLOGICAL MODIFIERS
-
批准号:3434281
-
项目类别:
-
资助金额:$0.75万
-
财政年份:1992
-
负责人:Robert W. Sidwell
-
依托单位:
国内基金
海外基金
Scalable Learning and Optimization: High-dimensional Models and Online Decision-Making Strategies for Big Data Analysis
-
批准号:--
-
项目类别:合作创新研究团队
-
资助金额:--
-
批准年份:2024
-
负责人:姚韬
-
依托单位:
新型手性NAD(P)H Models合成及生化模拟
-
批准号:20472090
-
项目类别:面上项目
-
资助金额:23.0万元
-
批准年份:2004
-
负责人:王乃兴
-
依托单位: