IN VITRO ANTIVIRAL SCREENS FOR RESPIRATORY VIRUSES

呼吸道病毒的体外抗病毒筛查

• 批准号: 6395043
• 负责人: Robert W. Sidwell
• 金额: $ 9万
• 依托单位: UTAH STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6395043
• 关键词: Adenoviridae; Hantavirus; Paramyxovirus; Picornaviridae; antiviral agents; drug screening /evaluation; influenzavirus A; measles virus; respiratory syncytial virus; respiratory virus; tissue /cell culture

项目成果

Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication.

香豆素和吡喃香豆素是抑制麻疹病毒复制的潜在新型药效团。

• DOI: 10.1177/095632020201300104
• 发表时间: 2002
• 期刊: Antiviral chemistry & chemotherapy
• 作者: Barnard,DaleL;Xu,ZeQi;Stowell,ValerieD;Yuan,Hongwei;Smee,DonaldF;Samy,Raghu;Sidwell,RobertW;Nielsen,MKim;Sun,Lihui;Cao,Hua;Li,Ailing;Quint,Clay;Deignan,Jeffrey;Crabb,Jennifer;Flavin,MichaelT
• 通讯作者: Flavin,MichaelT

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

N3,5-环-4-(β-D-呋喃核糖基)-vic-三唑并[4,5-b]吡啶-5-酮的合成，一种具有抗丙型肝炎病毒活性的新型化合物。

• DOI: 10.1021/jm0401210
• 发表时间: 2004
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Wang,Peiyuan;Hollecker,Laurent;Pankiewicz,KrzysztofW;Patterson,StevenE;Whitaker,Tony;McBrayer,TamaraR;Tharnish,PhillipM;Sidwell,RobertW;Stuyver,LievenJ;Otto,MichaelJ;Schinazi,RaymondF;Watanabe,KyoichiA
• 通讯作者: Watanabe,KyoichiA

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.

合成 N3,5-环-4-(β-D-呋喃核糖基)-vic-三唑并[4,5-b]吡啶-5-酮及其 3-脱氧糖类似物作为潜在的抗丙型肝炎病毒剂。

• DOI: 10.1081/ncn-200059314
• 发表时间: 2005
• 期刊: Nucleosides, nucleotides & nucleic acids
• 作者: Wang,Peiyuan;Hollecker,Laurent;Pankiewicz,KrzysztofW;Patterson,StevenE;Whitaker,Tony;McBrayer,TamaraR;Tharnish,PhillipM;Stuyver,LievenJ;Schinazi,RaymondF;Otto,MichaelJ;Watanabe,KyoichiA
• 通讯作者: Watanabe,KyoichiA

Inhibitors of measles virus.

麻疹病毒抑制剂。

• DOI: 10.1177/095632020401500301
• 发表时间: 2004
• 期刊: Antiviral chemistry & chemotherapy
• 作者: Barnard,DaleL

Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus.

白蛋白融合 1 型干扰素（白蛋白-干扰素-α 和白蛋白-干扰素-β）具有对抗生物恐怖分子 RNA 病毒和严重急性呼吸综合征 (SARS) 病毒的有效体外活性。

• DOI: 10.1159/000140361
• 发表时间: 2008
• 期刊: Chemotherapy
• 影响因子: 3.3
• 作者: Subramanian,GMani;Moore,PaulA;Gowen,BrianB;Olsen,AaronL;Barnard,DaleL;Paragas,Jason;Hogan,RobertJ;Sidwell,RobertW
• 通讯作者: Sidwell,RobertW