Understanding the biosynthesis of complex polyketide lipid toxins in pathogenic mycobacteria

了解致病性分枝杆菌中复杂聚酮脂质毒素的生物合成

• 批准号: nhmrc : 628640
• 负责人: Prof Tim Stinear
• 金额: $ 19.93万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-biosynthesis-complex-pathogenic-mycobacteria/101029
• 关键词: Understanding; biosynthesis; complex; polyketide; lipid

Some major infectious diseases such as tuberculosis are caused by bacteria that make very unusual lipids (fats) that can kill human cells or interfere with the human immune system. The aim of this project is to work out how bacteria make these lipids. This knowledge will open up new avenues for treatments to stop bacterial lipid production and prevent disease. There are also potential applications in harnessing the bacterial lipid machinery to make new drugs and a wide range of other chemicals.

一些主要的传染病，如肺结核，是由细菌引起的，这些细菌产生非常不寻常的脂质（脂肪），可以杀死人体细胞或干扰人体免疫系统。该项目的目的是研究细菌如何制造这些脂质。这些知识将为阻止细菌脂质产生和预防疾病的治疗开辟新的途径。在利用细菌脂质机制制造新药和其他各种化学品方面也有潜在的应用。