Data-led bioengineering to uncover hidden chemical wealth in bacteria

以数据为主导的生物工程揭示细菌中隐藏的化学财富

• 批准号: DP230102668
• 负责人: Prof Tim Stinear
• 金额: $ 48.67万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-05-26 至 2026-05-25
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102668
• 关键词: Data; led; bioengineering; uncover; hidden

The soil bacteria Nocardia are an untapped source of industrially prized chemical compounds called natural products. This project aims to develop innovative bioprospecting genomics technologies built from the disciplines of microbiology, biochemistry and computational statistics to discover hundreds of new natural products in Nocardia. This project will unlock the diversity of potent new enzymes and molecules with high economic value that could include insecticides to protect crops, bioactives to fight diseases, or new enzymes for food and biofuel production. This research unlocks enormous hidden chemical potential in soil bacteria, to build sustainable national economic growth through innovative, high-value industrial chemical development.

土壤细菌诺卡菌是一种未开发的工业上珍贵的化合物的来源，这种化合物被称为天然产物。该项目旨在开发基于微生物学、生物化学和计算统计学学科的创新生物勘探基因组技术，以发现诺卡迪亚菌中数百种新的天然产物。该项目将解锁具有高经济价值的强效新酶和分子的多样性，包括保护作物的杀虫剂、对抗疾病的生物活性物质，或用于食品和生物燃料生产的新酶。本研究揭示了土壤细菌中隐藏的巨大化学潜力，通过创新、高价值的工业化学发展，构建可持续的国民经济增长。