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REGULATION OF LENS FIBER CELL DIFFERENTIATION

REGULATION OF LENS FIBER CELL DIFFERENTIATION
晶状体纤维细胞分化的调节
批准号：
2888621
负责人：
MELINDA K DUNCAN
金额：
$25.38万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-07-01 至 2003-06-30
来源：
https://reporter.nih.gov/project-details/2888621
关键词：
DNA binding protein cataract cell differentiation crystallins developmental genetics fiber cell gel mobility shift assay gene expression genetic promoter element genetic regulation genetic regulatory element genetically modified animals laboratory mouse lens molecular cloning regulatory gene transcription factor transfection

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英文摘要
DESCRIPTION: The underlying cause of cataracts can often be shown to involve defects in lens fiber cell differentiation. The proposal seeks to elucidate the mechanisms controlling the high level, lens-specific expression of the bB1 crystallin gene, a crystallin expressed exclusively in differentiating lens fiber cells. The aims of the proposal are to determine the role of the Prox-1 homeodomain protein in activation of the bB1 gene, to determine the role of Pax6-mediated repression of bB1 promoter in fiber cell differentiation, to identify other transcription factors that are involved in regulating expression of the bB1 gene and finally to identify sequences in the bB1 crystallin gene promoter that are required for appropriate spatial and temporal expression of bB1 crystallin during fiber cell differentiation.
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