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RESEARCH TRAINING IN BLOOD AND VASCULAR BIOLOGY

血液和血管生物学研究培训

基本信息

批准号：
6145201
负责人：
SANDOR S SHAPIRO
金额：
$ 24.21万
依托单位：
THOMAS JEFFERSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-09-01 至 2001-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6145201
关键词：
RESEARCH TRAINING BLOOD VASCULAR BIOLOGY

项目摘要

This application seeks to amalgamate two training grants in hematology and in hemostasis and thrombosis under the new title "Blood and Vascular Biology". The purpose of our program continues to be the training of MDs and Ph.Ds in basic investigational approaches to problems in hematologic research and vascular biology. We are requesting annual support for 6 postdoctoral trainees. MDs will have completed general training as well as hematology/oncology clinical training and will have expressed a firm commitment to a career in academic medicine. Ph.Ds may be accepted immediately after receipt of their degree. Trainees will devote 2-3 years to full-time laboratory research, supplemented by frequent formal and informal research meetings, seminars and journal review sessions. In a separate track, a 3.4 year training program leading to a Ph.D. will be offered to selected M.D. trainees. For those trainees additional formal course work will be required. The training faculty consists of 15 senior and 5 junior investigators occupying approximately 25,000 square feet of laboratory space. Only senior faculty will have direct responsibility for a fellow's training program, although junior faculty will be actively involved in support of fellowship training. Areas of investigation include: signalling mechanisms in platelets, megakaryocytes, endothelial cells; megakaryocyte growth and differentiation; the roles of proteoglycans and sulfated proteins in platelet function and megakaryocyte maturation; platelet kinetics, metabolism and preservation; interaction of platelets and endothelial cells with plasma hemostatic factors and adhesive proteins; structure and function of the endothelial GpIb complex; angiogenesis and gene alterations during angiogenesis; effects of hypoxia on endothelial cell gene expression; regulation of plasminogen activator inhibitor-l gene expression; mechanisms of action of lupus anticoagulants and anticardiolipin antibodies; erythropoietin function and gene expression; red cell structure and function in the hemoglobinopathies; lymphocyte structure and function, with particular reference to NK cells; immunologic tolerance and adoptive cellular immunotherapy; antisense effects on leukemic cell growth and function; the genetic basis for leukemic abnormalities. Research activities under this training grant have already been reviewed by the IRB and IACUC committee in the form of individual research grants and contracts. No new research activities will be instituted solely under this training grant. The Cardeza Foundation, the Jefferson Cancer Institute, and associated laboratories are fully equipped to carry out the research programs outlined below. In addition, resources of the Cardeza Foundation library and conference room, medical illustration unit, clinical laboratory, and administrative facilities and personnel will be available for support of this training grant.

本申请旨在合并两项血液学培训赠款以及止血和血栓形成的新标题“血液和血管生物学”。我们计划的目的仍然是培养医学博士血液学问题基础研究方法的博士和博士研究和血管生物学。我们请求每年支持6 博士后研究生。医学博士也将完成一般培训作为血液学/肿瘤学临床培训，致力于学术医学事业。博士可以接受在获得学位后立即。学员将投入2-3年的时间全职实验室研究，辅以频繁的正式和非正式研究会议、研讨会和期刊评审会议。中独立的轨道，一个3.4年的培训计划，导致博士学位。将提供给选定的医学博士实习生对于这些受训人员，课程工作将是必需的。培训学院由15名高级和5名初级调查员，占地约25,000平方英尺，实验室空间只有高级教师将直接负责研究员的培训计划，虽然初级教师将积极参与支持研究金培训。调查领域包括：血小板、巨核细胞、内皮细胞细胞;巨核细胞的生长和分化; 蛋白聚糖和硫酸化蛋白在血小板功能中的作用，巨核细胞成熟;血小板动力学、代谢和保存; 血小板和内皮细胞与血浆止血剂的相互作用因子和粘附蛋白;内皮细胞的结构和功能 GpIb复合物;血管生成和血管生成过程中的基因改变; 缺氧对内皮细胞基因表达的影响; 纤溶酶原激活物通道-l基因表达;作用机制狼疮抗凝剂和抗心磷脂抗体;促红细胞生成素功能和基因表达;红细胞结构和功能，血红蛋白病;淋巴细胞结构和功能，特别是参考NK细胞;免疫耐受性和过继细胞免疫治疗;反义对白血病细胞生长和功能的影响; 白血病异常的遗传基础研究活动该培训补助金已经过IRB和IACUC的审查以个人研究赠款和合同的形式。没有新研究活动将仅在该培训补助金下开展。 Cardeza基金会，杰斐逊癌症研究所，以及相关的实验室设备齐全，可以进行研究计划概述如下。此外，Cardeza基金会图书馆的资源及会议室、医学图解组、临床化验室，以及将提供行政设施和人员，这个培训补助金。