Blood Research and EnhAnced Training against HIV in South Africa (BREATH-SA)

项目概要/摘要 南部非洲地区需要开展合作性生物医学研究培训，以提高和装备一个 在艾滋病毒恶性血液病方面的多样化但包容性的科学研究队伍，重点是艾滋病毒淋巴瘤 research.开普敦大学（UCT）血液学系拥有现有的D43 Fogarty补助金 与加州旧金山大学合作，专注于艾滋病毒相关的输血医学和血液学。 弗朗西斯科（加州大学旧金山分校），并正在申请这个补充的机会。UCT一直在研究 与两个历史上处于不利地位的机构在艾滋病毒相关的恶性血液病领域开展合作 (HDI)- 自由州大学和开普半岛科技大学。那里 非洲青年领导人迫切需要在一个综合和协作的环境中接受培训和培养能力， 研究设置。 我们已经确定了六名硕士生和四名博士毕业生从三个机构，所有来自 代表性不足的群体，他们将得到具体培训和指导研究的支持。拟议 该计划与母公司奖的范围密切相关，将侧重于临床研究方法 讲习班、实验室技能和方法讲习班、数据分析、数据登记和标本储存库。 就这项补助金而言，我们建议设立以下具体目标，以支持母补助金的目标： 继续建立UCT作为南非艾滋病毒血液学研究的卓越中心， 并解决研究机会的不平等。2)建立三方协作 生物医学研究培训网络与CPUT和UFS，以培养下一代临床研究人员， 艾滋病毒血液恶性肿瘤和淋巴瘤，成为独立的研究人员谁将解决新兴的 他们所服务的地区的健康挑战。 这笔补充赠款将扩大UCT，UFS和CPUT之间的研究培训网络。而且 为我们提供了一个机会，培训来自HDIs的代表性不足的科学家，并加强生物医学培训， 南非的HIV血液学

PROJECT SUMMARY/ABSTRACT Collaborative biomedical research training is needed in the Southern African region to raise up and equip a diverse yet inclusive scientific research corps in HIV hematological malignancy, with focus on HIV lymphoma research. The Hematology Division at the University of Cape Town (UCT) holds an existing D43 Fogarty grant focused on HIV-related Transfusion Medicine and Hematology together with the University of California San Francisco (UCSF) and is applying for this supplement opportunity. UCT has been building research collaborations in the field of HIV-related hematological malignancy with two historically disadvantaged institutions (HDI) - the University of the Free State (UFS) and the Cape Peninsula University of Technology (CPUT). There is a critical need for young African leaders to be trained and capacitated in an integrated and collaborative research setting. We have identified six Masters students and four PhD graduates from the three institutions, all from underrepresented groups, who will be supported with specific training and mentored research. The proposed program is closely aligned with the scope of the parent award and will focus on clinical research methods workshops, laboratory skills and methods workshops, data analysis, data registries and specimen repositories. For this supplement, we propose the following specific aims which support the aims of our parent grant: 1) The continued establishment of UCT as a South African center of excellence in HIV hematology research by reaching out to HDIs and by addressing inequities in research opportunity. 2) To establish a three-way collaborative biomedical research training network with CPUT and UFS to train the next generation of clinical researchers in HIV hematological malignancies and lymphoma, to become independent researchers who will address emerging health challenges in the regions they serve. This supplement grant will expand the research training network between UCT, UFS and CPUT. Additionally, it offers an opportunity for us to train underrepresented scientists from HDIs and strengthen biomedical training in HIV hematology in South Africa