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CRYSTALLOGRAPHIC STUDIES OF INTERLEUKIN 5 RECEPTOR

CRYSTALLOGRAPHIC STUDIES OF INTERLEUKIN 5 RECEPTOR
白细胞介素 5 受体的晶体学研究
批准号:
6315673
负责人:
PAUL CARR
金额:
$0.69万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-08-15 至 2000-08-14

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中文摘要
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英文摘要
We have crystallised the extracellular domain of the beta subunit of the interleukin-5 receptor. This is an important cytokine receptor that has been implicated in the pathogensis of Asthma and certain parasite infections. In order to facilitate derivativisation, a number of cysteine mutants have been produced. Some of the mutant crystals grow only to a small size. By using synchrotron radiation we should be able to (a) increase the resolution of data from our known derivative, (b) maximise the anomalous signal from the mercury atoms (c) collect data rapidly before icing becomes a problem, and (d) collect data from crystals of other potentially derivative mutants which do not grow large enough to diffract on our conventional source. BioCARS Station 14-BM-D was used.
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DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    8170033
  • 项目类别:
  • 资助金额:
    $0.03万
  • 财政年份:
    2010
  • 负责人:
    PAUL CARR
  • 依托单位:
DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    7954348
  • 项目类别:
  • 资助金额:
    $0.02万
  • 财政年份:
    2009
  • 负责人:
    PAUL CARR
  • 依托单位:
DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    7722000
  • 项目类别:
  • 资助金额:
    $0.15万
  • 财政年份:
    2008
  • 负责人:
    PAUL CARR
  • 依托单位:
DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    7598255
  • 项目类别:
  • 资助金额:
    $0.02万
  • 财政年份:
    2007
  • 负责人:
    PAUL CARR
  • 依托单位:
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