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CRYSTALLOGRAPHIC STUDIES OF INTERLEUKIN 5 RECEPTOR

CRYSTALLOGRAPHIC STUDIES OF INTERLEUKIN 5 RECEPTOR
白细胞介素 5 受体的晶体学研究
批准号:
6206353
负责人:
PAUL CARR
金额:
$1.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-08-15 至 2000-08-14

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中文摘要
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英文摘要
We have crystallised the extracellular domain of the beta subunit of the interleukin-5 receptor. This is an important cytokine receptor that has been implicated in the pathogensis of asthma and certain parasite infections. The crystals are weakly diffracting and it can take up to 10 days to collect a complete dataset on a rotating anode source. The effective resolution of the crystals is limited by the signal to noise ratio of the data collection system, being -3.5A on a rotaing anode and -2.6A on a synchrotron. In order to facilitate derivativisation, a number of cysteine mutants have been produced. Some of the mutant crystals grow only to a small size. These do not diffract when a rotating anode source is used. It has been shown that these crystals produce usable diffraction on 14 BM-C.
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DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    8170033
  • 项目类别:
  • 资助金额:
    $0.03万
  • 财政年份:
    2010
  • 负责人:
    PAUL CARR
  • 依托单位:
DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    7954348
  • 项目类别:
  • 资助金额:
    $0.02万
  • 财政年份:
    2009
  • 负责人:
    PAUL CARR
  • 依托单位:
DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    7722000
  • 项目类别:
  • 资助金额:
    $0.15万
  • 财政年份:
    2008
  • 负责人:
    PAUL CARR
  • 依托单位:
DIRECTED EVOLUTION OF BIOREMEDIAL ENZYMES
  • 批准号:
    7598255
  • 项目类别:
  • 资助金额:
    $0.02万
  • 财政年份:
    2007
  • 负责人:
    PAUL CARR
  • 依托单位:
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