USE OF BIOMARKERS TO MOTIVATE SMOKING CESSATION

使用生物标志物促进戒烟

• 批准号: 6203392
• 负责人: COLLEEN M MC BRIDE
• 金额: $ 34.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6203392
• 关键词: African American; behavior therapy; behavioral /social science research tag; biomarker; bleomycin; cancer prevention; cancer risk; carbon monoxide; clinical research; community health services; counseling; genetic counseling; genetic markers; genotype; health care cost /financing; human genetic material tag; human subject; human therapy evaluation; longitudinal human study; lung neoplasms; motivation; neoplasm /cancer education; self help; smoking cessation; tobacco abuse education

African Americans, particularly men, have high rates of smoking and concomitantly high rates of smoking-related cancers. Recent developments in the identification of genetic markers of susceptibility to tobacco related cancers provide exciting opportunities for developing innovative health education strategies that personalize risk and enhance motivation for smoking cessation. The proposed study is a five year randomized trial to evaluate the incremental improvement of providing biomarker feedback to state-of-the-science smoking cessation interventions to increase motivation and likelihood of cessation among African American smokers. Three intervention conditions will be tested in an additive study design. Patients who receive care at a community health clinic that serves a predominantly African American population will be screened for smoking status in the waiting rooms to identify current smokers. Smokers who agree to provide a breath and blood sample and take part in the smoking cessation intervention (n=620) will be randomized t one of three intervention conditions (1) Self-help guide plus motivational telephone counseling (Enhanced al care, n-160); (2) Self-help guide plus motivational tailored feedback that includes expired carbon monoxide (CO) results plus motivational telephone counseling (Exposure biomarker feedback, n=160); (3) Self-help guide plus tailored feedback that includes test results for CO and the presence of genetic biomarkers of susceptibility to lung cancer plus motivational telephone counseling (Susceptibility biomarker feedback, n-300). Data collection will include an in-person baseline survey, telephone follow-up surveys at 6,12, and 18 months, and collection of saliva samples to validate self-reported abstinence. The primary outcomes of interest will be motivation to quit smoking, point prevalence, and sustained abstinence at each follow-up. The proposed study is integrally linked to the overall project theme, "Improving Cancer Risk Communications." The framework for the CPRU enables us to assemble a multidisciplinary team that brings the best and brightest together to develop our communication approaches. The economics of scale inherent in the CPRU Cores will permit us to include cost effectiveness analysis and a solid biostatistical resource at modest cost.

非裔美国人，尤其是男性，吸烟率很高， 与吸烟相关的癌症的速率也很高。最近的发展 在鉴定烟草易感性的遗传标记中 相关癌症为发展创新提供了令人兴奋的机会 个性化风险并增强动力的健康教育策略 戒烟。拟议的研究是一项为期五年的随机试验 评估提供生物标志物反馈的增量改进 进行最先进的戒烟干预措施以增加 非裔美国人吸烟者停止的动机和可能性。 三种干预条件将在增材研究设计中进行测试。 在社区健康诊所接受护理的患者 主要是非洲裔美国人口吸烟的人口 候诊室的状态以识别当前的吸烟者。吸烟者谁 同意提供呼吸和血液样本并参加吸烟 戒烟干预（n = 620）将是随机t的三个之一 干预条件（1）自助指南加上动机电话 咨询（增强的Al Care，n-160）； （2）自助指南加上 激励性量身定制的反馈，包括过期的一氧化碳（CO） 结果加上动机电话咨询（曝光生物标志物 反馈，n = 160）; （3）自助指南以及量身定制的反馈 包括CO的测试结果和存在的存在 对肺癌的敏感性以及激励性电话咨询 （敏感性生物标志物反馈，N-300）。 数据收集将包括 面对面的基线调查，电话随访调查为6,12，以及 18个月，并收集唾液样品以验证自我报告 节制。感兴趣的主要结果将是退出的动力 每次随访时吸烟，点患病率和持续的戒酒。 拟议的研究与整个项目主题完全相关， “改善癌症风险交流。” CPRU的框架 使我们能够组装一个带来最好的多学科团队 最聪明，以发展我们的沟通方法。经济学 CPRU核心固有的规模将使我们能够包括成本 有效性分析和稳定的生物统计资源 成本。