CLINICAL CENTER FOR VIRAL ACTIVATION TRANSFUSION STUDY

病毒激活输血研究临床中心

• 批准号: 2721634
• 负责人: PRINCY N KUMAR
• 金额: $ 12.63万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2721634
• 关键词: HIV infections; blood filtration; cytomegalovirus; gamma radiation; human immunodeficiency virus 1; human subject; leukocyte activation /transformation; leukocyte transfusion; prognosis

This study's objective is to determine if transfusion is followed by the activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affecting prognosis. It also will evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion. The study consists of 11 clinical sites, a central laboratory, and a medical coordinating center.

这项研究的目标是确定输血之后是否是 HIV-1感染者中HIV-1和巨细胞病毒（CMV）的激活 从而对预后产生不利影响。 它还会评估角色 通过检查的供体白细胞来检查 通过过滤或废除其能力来清除白细胞 通过γ辐射扩散。 最后，研究将检查 输血后供体淋巴细胞的持久性。 该研究包括11个临床部位，一个中央实验室和一个 医疗协调中心。