CLINICAL CENTER FOR VIRAL ACTIVATION TRANSFUSION STUDY

病毒激活输血研究临床中心

• 批准号: 6199169
• 负责人: PRINCY N KUMAR
• 金额: $ 1.4万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6199169
• 关键词: HIV infections; blood filtration; cytomegalovirus; gamma radiation; human immunodeficiency virus 1; human subject; leukocyte activation /transformation; leukocyte transfusion; prognosis

This study's objective is to determine if transfusion is followed by the activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affecting prognosis. It also will evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion. The study consists of 11 clinical sites, a central laboratory, and a medical coordinating center.

这项研究的目的是确定输血后是否有

项目成果

Increased human T-lymphotropic virus type II proviral load following highly active retroviral therapy in HIV-coinfected patients.

HIV 合并感染患者接受高效逆转录病毒治疗后，人类 T 淋巴细胞病毒 II 型前病毒载量增加。

• DOI: 10.1097/00126334-200308150-00019
• 发表时间: 2003
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Murphy,EdwardL;Grant,RobertM;Kropp,Jerry;Oliveira,Adriano;Lee,Tzong-Hae;Busch,MichaelP
• 通讯作者: Busch,MichaelP