MICRORADIOGRAPHIC IMAGER FOR NEUROVASCULAR INTERVENTION

总体目标是建立显微射线照相，小视场 用于检测小血管（如穿孔和特征）的成像仪 例如支架金属丝，这对现在和未来的脑- 血管介入，但可能无法正常可视化， 今天的系统。新摄像机将与基于导管的 微创手术提供非常高的分辨率（10线 每毫米对）的数字图像。 介入部位。ROI微血管造影成像仪将基于 高分辨率的X射线吸收磷光体， 大面积硅片电荷耦合器件光纤拉锥 (CCD)光传感器一系列越来越自动化的插入 机制和计算机工作站将被开发， 定位摄像机并与标准血管造影成像一起使用 设备.一旦建立和物理特性，微- 血管造影ROI摄像机将在以下方面进行评价： 改善的成像能力可能在神经血管 介入治疗，其中诸如支架和线圈之类的装置或诸如 当放置胶水以治疗血管狭窄、动脉瘤 动静脉畸形广泛的体模和动物研究， 测试对特定干预任务的适用性 同时逐渐应用于人类程序， 临床介入医生的评估。的效果 来自新相机的附加高分辨率图像可以在每个 干预者在干预过程中做出的决定 将对手术进行分析，以确定手术是否 改变和改进。适用于单平面和双平面微型 血管造影术和为3D渲染血管模型提供数据将 追究

The overall goal is to build micro-radiographic, small field-of-view imagers for detecting small vessels such as perforators and features such as stent wires which may be crucial to present and future cerebro- vascular interventions but which may not be normally visualized with present day systems. The new cameras will be used with catheter-based minimally invasive procedures to provide very high resolution (10 line pairs per mm) digital images of a region of interest (ROI) around the interventional site. The ROI micro-angiographic imagers will be based on a high resolution x-ray absorbing phosphor viewed through a slight fiberoptic taper by a large area silicon chip charge coupled device (CCD) light sensor. A series of increasingly automated insertion mechanisms and a computer workstation will be developed to allow the camera to be positioned and used with standard angiographic imaging equipment. Once built and characterized physically, the micro- angiographic ROI cameras will be evaluated in terms of the role such improved imaging capability might have during neuro-vascular interventions where devices such as stents and coils or materials such as glue are placed so as to treat vessel stenoses, aneurysms and arteriovenous malformations. Extensive phantom and animal studies to test the applicability to specific interventional tasks will occur simultaneously with gradual application to human procedures and evaluation by clinical interventionalists. The effect that the additional high resolution images from the new cameras may have on each decision made by the interventionalist during the course of the procedure will be analyzed to determine whether the procedure was altered and improved. Use for both single-plane and bi-plane micro- angiography and for providing data for 3D rendered vascular models will be investigated.