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Radiographic guidance of new cerebral aneurysm stent

新型脑动脉瘤支架的影像引导

基本信息

批准号：
7222689
负责人：
STEPHEN RUDIN
金额：
$ 62.59万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-04-15 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7222689
关键词：
Aneurysm Angiography Animal Model Area Blood Vessels Blood flow Cataloging Catalogs Categories Catheters Cerebral Aneurysm Characteristics Classification Clinical Computers Condition Contrast Media Development Device Designs Device or Instrument Development Devices Diagnostic Imaging Dyes Environment Evaluation Goals Hemorrhage Human Image Image Analysis Imagery Implant Insurance Claim Review Liquid substance Literature Localized Mechanics Methods Modeling Modification Nature Neck Optics Pattern Peer Review Perforation Placement Porosity Positioning Attribute Procedures Publishing Recurrence Resolution Risk Secrecy Shapes Standards of Weights and Measures Stents Stress Surveys Thrombosis Time Velocimetries Viscosity base clinical application density design desire detector imaging detector improved innovation particle prototype research study size treatment planning

项目摘要

DESCRIPTION (provided by applicant): The limitations of radiographic visualization and the lack of consideration of the influence of stentt deployment on details of blood flow have limited stentt design to forms which are uniform and circularly symmetric. Yet some of the most important potential applications of stents such as in the treatment of aneurysms are inherently non-uniform and non-symmetric in nature. In this project, the design of innovative asymmetric stents and their deployment enabled by guidance with new high resolution x-ray image detectors are investigated. In particular, the limitations and accuracy in localizing the rotational orientation as well as the longitudinal distance of small asymmetric devices delivered by catheters within the vasculature under radiographic guidance are explored for the first time. This new capability for accurate localization will allow the implementation of new devices such as asymmetric, variable porosity stentts for treatment of cerebral aneurysms by modifying aneurysm blood flow characteristics. To optimize the new stentt design, flow reduction in aneurysms needed to induce thrombosis will be explored. Also details of flow and flow modification will be investigated using advanced theoretical and experimental methods. It is expected that this new capability should enable more rapid treatment of aneurysms with less chance of hemorrhage and decreased possibility for recurrence compared with existing procedures and additionally readily enable treatment of wide-necked and giant cerebral aneurysms for the first time.

描述（由申请人提供）：

项目成果

期刊论文数量（30）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Component analysis of a new Solid State X-ray Image Intensifier (SSXII) using photon transfer and Instrumentation Noise Equivalent Exposure (INEE) measurements.

DOI：
10.1117/12.813957
发表时间：
2009-01-01
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
0
作者：
Kuhls-Gilcrist A;Bednarek DR;Rudin S
通讯作者：
Rudin S

Modification of the NEMA XR21-2000 cardiac phantom for testing of imaging systems used in endovascular image guided interventions.

改进 NEMA XR21-2000 心脏模型，用于测试血管内图像引导干预中使用的成像系统。

DOI：
10.1117/12.813533
发表时间：
2009
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
0
作者：
Ionita,CN;Dohatcu,A;Jain,A;Keleshis,C;Hoffmann,KR;Bednarek,DR;Rudin,S
通讯作者：
Rudin,S

Evaluation of a second-generation self-expanding variable-porosity flow diverter in a rabbit elastase aneurysm model.

DOI：
10.3174/ajnr.a2548
发表时间：
2011-09
期刊：
AJNR. American journal of neuroradiology
影响因子：
0
作者：
Ionita CN;Natarajan SK;Wang W;Hopkins LN;Levy EI;Siddiqui AH;Bednarek DR;Rudin S
通讯作者：
Rudin S

In vivo assessment of rapid cerebrovascular morphological adaptation following acute blood flow increase.