Radiographic guidance of new cerebral aneurysm stent

描述(由申请人提供)： 由于放射学可视化的局限性以及支架置放对血流细节影响的缺乏，使得支架的设计局限于均匀和圆形对称的形状。然而，支架的一些最重要的潜在应用，如在治疗动脉瘤方面，本质上是不均匀和非对称的。在这个项目中，研究了新型非对称支架的设计及其在新型高分辨率X射线图像探测器引导下的部署。特别是，首次探讨了在放射学引导下血管内导管传递的小的非对称装置在旋转方向和纵向距离定位方面的局限性和准确性。这种精确定位的新能力将允许实施新的设备，如不对称、可变孔隙率支架，通过改变动脉瘤的血流特征来治疗脑动脉瘤。为了优化新的支架设计，将探索导致血栓形成所需的动脉瘤的血流减少。此外，还将使用先进的理论和实验方法研究流动和流动修改的细节。预计这一新能力将能够更快地治疗动脉瘤，与现有程序相比，出血的机会更少，复发的可能性也更低，此外，还可以第一次容易地治疗宽颈和巨大的脑动脉瘤。

DESCRIPTION (provided by applicant): The limitations of radiographic visualization and the lack of consideration of the influence of stentt deployment on details of blood flow have limited stentt design to forms which are uniform and circularly symmetric. Yet some of the most important potential applications of stents such as in the treatment of aneurysms are inherently non-uniform and non-symmetric in nature. In this project, the design of innovative asymmetric stents and their deployment enabled by guidance with new high resolution x-ray image detectors are investigated. In particular, the limitations and accuracy in localizing the rotational orientation as well as the longitudinal distance of small asymmetric devices delivered by catheters within the vasculature under radiographic guidance are explored for the first time. This new capability for accurate localization will allow the implementation of new devices such as asymmetric, variable porosity stentts for treatment of cerebral aneurysms by modifying aneurysm blood flow characteristics. To optimize the new stentt design, flow reduction in aneurysms needed to induce thrombosis will be explored. Also details of flow and flow modification will be investigated using advanced theoretical and experimental methods. It is expected that this new capability should enable more rapid treatment of aneurysms with less chance of hemorrhage and decreased possibility for recurrence compared with existing procedures and additionally readily enable treatment of wide-necked and giant cerebral aneurysms for the first time.