Radiographic guidance of new cerebral aneurysm stent

描述（由申请人提供）： 影像学可视化的局限性和缺乏考虑支架展开对血流细节的影响，限制了支架设计为均匀和圆形对称的形式。然而，支架的一些最重要的潜在应用，例如在动脉瘤的治疗中，本质上是固有的不均匀和不对称的。在该项目中，研究了创新的非对称支架的设计及其在新型高分辨率X射线图像探测器引导下的部署。特别是，在定位的旋转方向，以及由导管在血管系统内的放射线引导下的纵向距离的小的不对称设备的局限性和准确性进行了探索的第一次。这种精确定位的新能力将允许实施新器械，例如通过改变动脉瘤血流特性治疗脑动脉瘤的不对称、可变孔隙度支架。为了优化新的支架设计，将探索诱导血栓形成所需的动脉瘤中的血流减少。还将使用先进的理论和实验方法研究流动和流动修改的细节。与现有手术相比，预计这种新功能可以更快速地治疗动脉瘤，减少出血机会，降低复发可能性，并且还可以方便地首次治疗宽颈和巨大脑动脉瘤。

DESCRIPTION (provided by applicant): The limitations of radiographic visualization and the lack of consideration of the influence of stentt deployment on details of blood flow have limited stentt design to forms which are uniform and circularly symmetric. Yet some of the most important potential applications of stents such as in the treatment of aneurysms are inherently non-uniform and non-symmetric in nature. In this project, the design of innovative asymmetric stents and their deployment enabled by guidance with new high resolution x-ray image detectors are investigated. In particular, the limitations and accuracy in localizing the rotational orientation as well as the longitudinal distance of small asymmetric devices delivered by catheters within the vasculature under radiographic guidance are explored for the first time. This new capability for accurate localization will allow the implementation of new devices such as asymmetric, variable porosity stentts for treatment of cerebral aneurysms by modifying aneurysm blood flow characteristics. To optimize the new stentt design, flow reduction in aneurysms needed to induce thrombosis will be explored. Also details of flow and flow modification will be investigated using advanced theoretical and experimental methods. It is expected that this new capability should enable more rapid treatment of aneurysms with less chance of hemorrhage and decreased possibility for recurrence compared with existing procedures and additionally readily enable treatment of wide-necked and giant cerebral aneurysms for the first time.