EPIDEMIOLOGY OF HUMAN RETROVIRUSES IN BLOOD DONORS

献血者中人类逆转录病毒的流行病学

• 批准号: 6158424
• 负责人: GEORGE B SCHREIBER
• 金额: $ 194.9万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-17 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6158424
• 关键词: HIV infections; Retroviridae; antiviral antibody; blood banks; blood donor; clinical research; communicable disease control; data collection; disease /disorder proneness /risk; epidemiology; hepatitis B; hepatitis C; human T cell lymphotropic virus type 1; human T cell lymphotropic virus type 2; human immunodeficiency virus 1; human immunodeficiency virus 2; human subject; longitudinal human study; mass screening; serology /serodiagnosis

The contractor shall serve as the coordinating center for the Epidemiologic Studies of Human Retroviruses in Volunteer Blood Donors program. The objectives are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence incidence, and risk factors: 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.

承包商应作为协调中心， 无偿献血者逆转录病毒感染的流行病学研究 程序. 目的如下：1）确定逆转录病毒的流行情况 第一次献血者的血清阳性率; 2）确定 重复献血者逆转录病毒血清转化作为衡量 感染发生率; 3）确定抗体阳性的危险因素 献血者; 4）通过地理位置表征血液群体， 年龄、性别、种族/民族和献血史，以允许分析 患病率和危险因素：5）确定 逆转录病毒阳性血液单位，并进行临床和实验室 这些接受者的后续行动，以确定这些 6）建立血液标本库， 长期储存来自研究供体和受体的标本， 未来的测试