EPIDEMIOLOGY OF HUMAN RETROVIRUSES IN BLOOD DONORS

承包商应作为协调中心， 无偿献血者逆转录病毒感染的流行病学研究 程序. 目的如下：1）确定逆转录病毒的流行情况 第一次献血者的血清阳性率; 2）确定 重复献血者逆转录病毒血清转化作为衡量 感染发生率; 3）确定抗体阳性的危险因素 献血者; 4）通过地理位置表征血液群体， 年龄、性别、种族/民族和献血史，以允许分析 患病率和危险因素：5）确定 逆转录病毒阳性血液单位，并进行临床和实验室 这些接受者的后续行动，以确定这些 6）建立血液标本库， 长期储存来自研究供体和受体的标本， 未来的测试

The contractor shall serve as the coordinating center for the Epidemiologic Studies of Human Retroviruses in Volunteer Blood Donors program. The objectives are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence incidence, and risk factors: 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.