EPIDEMIOLOGY OF HUMAN RETROVIRUSES IN BLOOD DONORS

承包商应作为以下项目的协调中心 无偿献血人群中人类逆转录病毒的流行病学研究 程序。 目标如下：1)确定逆转录病毒的流行率 首次献血者血清阳性率；2)测定 重复献血者中逆转录病毒血清转换作为衡量 感染发生率；3)确定抗体阳性的危险因素 献血者；4)按地理位置描述血液人口的特征， 年龄、性别、种族/民族和捐赠史，以便对 患病率和危险因素：5)确定接受者 逆转录病毒阳性血液单位和进行临床和实验室 对这些接受者进行随访，以确定这些病毒的传播性 通过输血试剂；以及6)建立血样储存库 长期保存来自研究捐赠者和受赠者的标本 未来的测试。

The contractor shall serve as the coordinating center for the Epidemiologic Studies of Human Retroviruses in Volunteer Blood Donors program. The objectives are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence incidence, and risk factors: 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.