EPIDEMIOLOGY OF HUMAN RETROVIRUSES IN BLOOD DONORS

承包商应作为协调中心 无偿献血者中人类逆转录病毒的流行病学研究 程序。 目标如下：1）确定逆转录病毒的流行情况 首次献血者血清呈阳性； 2) 确定速率 重复献血者的逆转录病毒血清转化作为衡量 感染发生率； 3) 确定抗体阳性的危险因素 捐助者； 4) 按地理位置描述血群特征， 年龄、性别、种族/民族和捐赠历史，以便进行分析 患病率和危险因素：5) 确定接受者 逆转录病毒阳性血液单位并进行临床和实验室检查 对这些接收者进行跟踪以确定这些接收者的可传播性 通过输血进行治疗； 6) 建立血液样本库 长期储存研究捐赠者和接受者的标本 未来的测试。

The contractor shall serve as the coordinating center for the Epidemiologic Studies of Human Retroviruses in Volunteer Blood Donors program. The objectives are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence incidence, and risk factors: 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.