EPIDEMIOLOGY OF HUMAN RETROVIRUSES IN BLOOD DONORS

献血者中人类逆转录病毒的流行病学

• 批准号: 2661618
• 负责人: GEORGE B SCHREIBER
• 金额: $ 179.51万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-17 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2661618
• 关键词: EPIDEMIOLOGY; HUMAN; RETROVIRUSES; BLOOD; DONORS

The contractor shall serve as the coordinating center for the Epidemiologic Studies of Human Retroviruses in Volunteer Blood Donors program. The objectives are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence incidence, and risk factors: 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.

承包商应作为以下项目的协调中心 无偿献血人群中人类逆转录病毒的流行病学研究 程序。 目标如下：1)确定逆转录病毒的流行率 首次献血者血清阳性率；2)测定 重复献血者中逆转录病毒血清转换作为衡量 感染发生率；3)确定抗体阳性的危险因素 献血者；4)按地理位置描述血液人口的特征， 年龄、性别、种族/民族和捐赠史，以便对 患病率和危险因素：5)确定接受者 逆转录病毒阳性血液单位和进行临床和实验室 对这些接受者进行随访，以确定这些病毒的传播性 通过输血试剂；以及6)建立血样储存库 长期保存来自研究捐赠者和受赠者的标本 未来的测试。