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NEURONS AND CIRCUITS OF PERIOLIVARY NUCLEI

橄榄周核的神经元和回路

基本信息

批准号：
2856601
负责人：
ALBERT S BERREBI
金额：
$ 16.38万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-01-01 至 2000-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2856601
关键词：
afferent nerve auditory feedback auditory pathways binaural hearing immunocytochemistry laboratory rat neuronal transport neurons olivary body tissue /cell preparation transmission electron microscopy

项目摘要

The mammalian superior olivary complex (SOC) consists of three well defined cell groups, the medical superior olive, lateral superior olive and medical nucleus of the trapezoid body, which have identified roles in sound localization. These principal nuclei are surrounded by a sphere of accessory cell groups, collectively known as periolivary nuclei (PON). To a large extent, the PON are involved in the descending auditory pathway and participate in reflexive and feedback functions of the SOC. This application focuses on a specific periolivary region known as the superior paraolivary nucleus (SPON) in rodents (the dorsomedial periolivary nucleus DMPO, in non-rodents). This cell group is the largest of the PON in many species, approaching the size of the principal nuclei, but has received relatively little attention. By all accounts, the SPON appears to be a very complex structure, both in terms of its morphological and neurochemical characteristics and in terms of its participation with various aspects of the auditory pathway. By virtue of its relationship with other nuclei in the SOC, the SPON may play a role in binaural processing. The SPON is also a site of convergence of ascending and descending auditory projections, and may serve an important role in modulating the activity of descending systems. The long term aim of this research is to provide a better understanding of the functional role of this cell group. The proposed study combines classical neuroanatomical preparations with immunocytochemistry, electron microscopy an pathway tracing to perform the most comprehensive study to date of the SPON of the rat. A systematic strategy, involving increasingly detailed levels of analysis, will guide the project to its goal of providing a precise, quantitative characterization of the nucleus and its connectivity. The experiments will also uncover the topographic organization of the nucleus. This research will contribute to a better overall understanding of the auditory brainstem. in the long term, such information will be critical to the design of prosthetic devices that may replace non-functioning parts of the central auditory system.

哺乳动物上橄榄复合体(SOC)由三个明确的细胞群：医用上橄榄、侧上橄榄和医用上橄榄梯形身体的核，它们识别声音中的角色本地化。这些主核被一个球体围绕着附属细胞群，统称为橄榄周核(PON)。至 PON在很大程度上参与了下行听觉通路和参与SOC的反身和反馈功能。这个应用程序聚焦于一个特定的橄榄周区，称为啮齿动物的上橄榄旁核(背内侧橄榄周核) DMPO核，在非啮齿动物中)。该小区组是无源光网络中最大的在许多物种中，接近主核的大小，但有受到的关注相对较少。根据所有人的说法，海绵似乎是一个非常复杂的结构，无论是在形态上还是在神经化学特征及其参与听觉通路的各个方面。凭借它的关系与SOC中的其他核团一起，Spon可能在双耳中发挥作用正在处理。Spon也是提升和融合的地点下降的听觉投射，并可能在调节下行系统的活动。这样做的长期目标是研究的目的是为了更好地理解这个细胞群。这项拟议的研究将经典的神经解剖学准备与免疫细胞化学、电子显微镜和途径追踪以执行迄今为止对老鼠幼体的最全面的研究。一个系统的战略，包括越来越详细的分析水平，将指导该项目为其目标提供了精确的、定量的原子核及其连通性的表征。这些实验将会也揭示了原子核的地形组织。这项研究将有助于更好地从整体上理解听觉脑干。从长远来看，这些信息将对假体装置的设计，可以取代不起作用的部分中枢听觉系统。