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ORAL DRUG ABUSE--DETERMINANTS AND CONSEQUENCES

口服药物滥用——决定因素和后果

基本信息

批准号：
2872038
负责人：
JOHN L FALK
金额：
$ 9.45万
依托单位：
RUTGERS, THE STATE UNIV OF N.J.
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-02-01 至 2000-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2872038
关键词：
caffeine cocaine drug abuse drug interactions high performance liquid chromatography laboratory rat midazolam nicotine oral administration performance pharmacokinetics preference psychomotor function psychopharmacology reinforcer self medication substance abuse related behavior

项目摘要

Request for ADAMHA Research Scientist Award. (1) Oral, schedule-induced (S-I) drug overindulgence, and chronic drug preference compared to vehicle, will be studied, especially as determined by the history of the environmental stimulus control (S/D) of preference, and current pharmacological factors. Drugs considered will be extended from cocaine to caffeine, midazolam and nicotine. Emphasis will be on tracing the situational sources initiating and maintaining drug abuse under conditions wherein pharmacologic impact is minimized, but functionally significant (oral route), while the environmental determination (S-I and S/D control) of the behavior maximized. This endeavors to clarify drug abuse initiation by an analysis of the gateways, both situational and pharmacologic, that make its acquisition probable. (2) Excessive drug intake can compromise ensuing behavioral functions. Both unconditioned behavior (e.g., locomotor activity) and psychomotor performance (e.g., fine-motor control and timing behaviors) will be measured after acute and chronic oral drug self-administration, and the resulting profiles related to a drug's measured serum concentration-time profile. (3) Results from oral self-administration will be compared to those of parenteral drug imposition. The aim is to predict whether serum pharmacokinetic concentration-time profiles of parent compounds and their active metabolites predict the concurrent behavior-time profiles. (4) Studies pay special attention to the behavior and kinetics of drug interactions, as concurrent use and abuse of substances, both licit and illicit, commonly occurs.

申请 ADAMHA 研究科学家奖。 (1) 口头的、日程安排引起的 (S-I) 药物过度放纵和长期药物偏好与车辆，将被研究，特别是由历史确定的偏好的环境刺激控制（S/D）和当前的药理因素。考虑的药物将由可卡因扩展咖啡因、咪达唑仑和尼古丁。重点将放在追踪情境来源在一定条件下引发和维持药物滥用其中药理学影响最小化，但功能显着（口服途径），而环境测定（S-I和S/D对照）行为最大化。此举旨在澄清药物滥用问题通过对网关的分析来启动，包括情境和药理学，这使得其获得成为可能。 (2)用药过量摄入会损害随后的行为功能。两者均无条件行为（例如运动活动）和精神运动表现（例如精细运动控制和计时行为）将在急性和慢性口服药物自我给药，以及由此产生的相关概况药物的测量血清浓度-时间曲线。 (3) 结果口服自我给药将与肠胃外药物进行比较征收。目的是预测血清药代动力学是否母体化合物及其活性的浓度-时间曲线代谢物预测并发行为-时间曲线。（四）研究特别注意药物相互作用的行为和动力学，同时使用和滥用合法和非法物质，常发生。