ORAL DRUG ABUSE--DETERMINANTS AND CONSEQUENCES

申请ADAMHA研究科学家奖。(1)口头、日程安排 (S-I)药物过度放纵，与慢性药物偏好相比 车辆，将被研究，特别是由 环境刺激控制(S/D)的偏好，和当前 药理因素。被考虑的药物将从可卡因扩展到 咖啡因、咪达唑仑和尼古丁。重点将放在追踪 在有条件的情况下启动和维持药物滥用的情景来源 其中药理影响最小，但在功能上意义重大 (口服路线)，而环境测定(S-I和S/D控制) 最大化的行为。这是为了澄清药物滥用。 通过对网关的分析来发起，包括情景和 从药理上讲，这使得它有可能被收购。(2)药物过量 摄入可能会损害随后的行为功能。都是无条件的 行为(例如，运动活动)和精神运动表现(例如， 精细运动控制和计时行为)将在急性和 慢性口服药物自我给药及由此产生的相关情况 一种药物测量的血药浓度-时间曲线。(3)结果： 口服自我给药将与静脉给药进行比较。 强制执行。其目的是预测血清药代动力学 母体化合物及其活性的浓度-时间分布 代谢物预测并发行为-时间分布。(4)研究 特别关注药物相互作用的行为和动力学， 由于合法和非法物质的同时使用和滥用， 通常会发生。

Request for ADAMHA Research Scientist Award. (1) Oral, schedule-induced (S-I) drug overindulgence, and chronic drug preference compared to vehicle, will be studied, especially as determined by the history of the environmental stimulus control (S/D) of preference, and current pharmacological factors. Drugs considered will be extended from cocaine to caffeine, midazolam and nicotine. Emphasis will be on tracing the situational sources initiating and maintaining drug abuse under conditions wherein pharmacologic impact is minimized, but functionally significant (oral route), while the environmental determination (S-I and S/D control) of the behavior maximized. This endeavors to clarify drug abuse initiation by an analysis of the gateways, both situational and pharmacologic, that make its acquisition probable. (2) Excessive drug intake can compromise ensuing behavioral functions. Both unconditioned behavior (e.g., locomotor activity) and psychomotor performance (e.g., fine-motor control and timing behaviors) will be measured after acute and chronic oral drug self-administration, and the resulting profiles related to a drug's measured serum concentration-time profile. (3) Results from oral self-administration will be compared to those of parenteral drug imposition. The aim is to predict whether serum pharmacokinetic concentration-time profiles of parent compounds and their active metabolites predict the concurrent behavior-time profiles. (4) Studies pay special attention to the behavior and kinetics of drug interactions, as concurrent use and abuse of substances, both licit and illicit, commonly occurs.