ORAL DRUG ABUSE--DETERMINANTS AND CONSEQUENCES

过量口服药物的决定因素和后果 将探索通过时间表诱导的烦渴的自我给药， 强调口服可卡因（COC）和苯二氮卓类（BZ）滥用变量， 精细运动表现的后果：（A：COC）（1）改善 通过急性和慢性治疗过量COC摄入， 治疗剂（例如，地昔帕明，马吲哚）和（2）替代品 COC摄入（例如，其他解决方案，活动轮）。 (3)加重 通过注射尼古丁（NIC）和咖啡因（CAF）滥用COC。 (4)的 通过首先建立一个历史， 合法药物多饮（NIC，CAF），（5）可能的行为免疫 （情景替代的历史）对COC滥用收购。 的 急性和慢性注射和停药的后果 辨别性运动表现，以及COC与NIC的相互作用， 咖啡馆。 （B：BZ）（1）阻断剂对BZ过量摄入的改善作用（Ro 15 - 1788，CGS 8216）和（2）因CAF或镇静剂使用史而加重 （乙醇）滥用。 (3)急、慢性药物抗焦虑作用评价 通过采用由这样的人过度摄取NaCl溶液的方法， 剂. (3)每天反弹的精细运动控制后果， 长期暴露于咪达唑仑（例如，也许被反方夸大了 激动剂[FG 7142]探针）和咪达唑仑-CAF相互作用。 对于两个COC 和BZ时，将测量药物和代谢物的血清水平， 关于慢性滥用量和与运动相关的水平， 性能中断。

The determinants and consequences of excessive oral drug self-administration by schedule-induced polydipsia will be explored, emphasizing oral cocaine (COC) and benzodiazepine (BZ) abuse variables and fine-motor performance consequences: (A: COC) (1) The amelioration of excessive COC intake by acute and chronic treatment with possible therapeutic agents (e.g., desipramine, mazindol) and by (2) alternatives to COC ingestion (e.g., other solutions, activity wheel). (3) Exacerbation of COC abuse by injections of nicotine (NIC) and caffeine (CAF). (4) The gateways to exacerbated COC abuse by first instituting a history of licit-drug polydipsia (NIC, CAF), and (5) possible behavioral immunization (history of situational alternatives) against COC abuse acquisition. The consequences of acute and chronic injection and withdrawal of COC for discriminative motor performance, as well as COC interactions with NIC and CAF. (B: BZ) (1) The amelioration of excessive BZ intake by blockers (Ro 15-1788, CGS 8216) and (2) its exacerbation by CAF or a history of sedative (ethanol) abuse. (3) Acute and chronic drug anxiolytic action evaluation by a method employing the exaggerated ingestion of NaC1 solutions by such agents. (3) The fine motor control consequences of daily rebound from chronic exposure to midazolam (e.g., as perhaps exaggerated by inverse agonist [FG 7142] probes) and of midazolam-CAF interactions. For both COC and BZs, serum levels of drug and metabolites will be measured, both with respect to chronic amounts abused and the levels associated with motor performance disruption.