ORAL DRUG ABUSE: DETERMINANTS AND CONSEQUENCES

口服药物过量的决定因素和后果 将探索由时间表引起的多饮的自我给药， 强调口服可卡因(COC)和苯二氮卓类(BZ)滥用变量和 细电机性能后果：(A：COC)(1)改进 通过急性和慢性治疗摄入过量的COC，可能 治疗剂(例如，地昔帕明、马吲哚)和(2)替代品 COC摄取(例如，其他解决方案、活动轮)。(3)病情加重 通过注射尼古丁(NIC)和咖啡因(CAF)滥用COC。(4) 通过首先建立一个历史来加剧COC滥用的门户 合法药物多饮(NIC，CAF)，以及(5)可能的行为免疫 (情景选择的历史)反对COC滥用收购。这个 急、慢性注射COC和停用COC的后果 区分运动性能，以及COC与NIC和 咖啡馆。(B：BZ)(1)阻滞剂改善BZ过量摄取(Ro 15-1788，CGS 8216)和(2)CAF或镇静剂史加重 (乙醇)滥用。(3)急、慢性药物抗焦虑作用评价 通过使用这样的夸大摄取NaCI溶液的方法 探员们。(3)每日反弹的精细马达控制后果 长期接触咪达唑仑(例如，可能被反转夸大了 激动剂[FG 7142]探针)和咪达唑仑-CAF相互作用。对于两个COC 和BZS，将测量血清药物和代谢物的水平，两者都是 关于长期滥用的数量和与运动相关的水平 性能中断。

The determinants and consequences of excessive oral drug self-administration by schedule-induced polydipsia will be explored, emphasizing oral cocaine (COC) and benzodiazepine (BZ) abuse variables and fine-motor performance consequences: (A: COC) (1) The amelioration of excessive COC intake by acute and chronic treatment with possible therapeutic agents (e.g., desipramine, mazindol) and by (2) alternatives to COC ingestion (e.g., other solutions, activity wheel). (3) Exacerbation of COC abuse by injections of nicotine (NIC) and caffeine (CAF). (4) The gateways to exacerbated COC abuse by first instituting a history of licit-drug polydipsia (NIC, CAF), and (5) possible behavioral immunization (history of situational alternatives) against COC abuse acquisition. The consequences of acute and chronic injection and withdrawal of COC for discriminative motor performance, as well as COC interactions with NIC and CAF. (B: BZ) (1) The amelioration of excessive BZ intake by blockers (Ro 15-1788, CGS 8216) and (2) its exacerbation by CAF or a history of sedative (ethanol) abuse. (3) Acute and chronic drug anxiolytic action evaluation by a method employing the exaggerated ingestion of NaC1 solutions by such agents. (3) The fine motor control consequences of daily rebound from chronic exposure to midazolam (e.g., as perhaps exaggerated by inverse agonist [FG 7142] probes) and of midazolam-CAF interactions. For both COC and BZs, serum levels of drug and metabolites will be measured, both with respect to chronic amounts abused and the levels associated with motor performance disruption.