ORAL DRUG ABUSE--DETERMINANTS AND CONSEQUENCES

申请ADAMHA研究科学家奖。 (1)经口给药，时间表诱导 (S-I)药物过度放纵和慢性药物偏好， 车辆，将进行研究，特别是根据历史的决定， 环境刺激控制（S/D）的偏好，和电流 药理因素 考虑的毒品将从可卡因扩展到 咖啡因咪达唑仑和尼古丁 重点将放在追踪 在一定条件下引发和维持药物滥用的情景来源 其中药理学影响被最小化，但功能显著 (oral路线），而环境测定（S-I和S/D控制） 最大化的行为。 这是为了澄清药物滥用 通过分析网关启动，包括情境和 药理学，这使得它的收购可能。 (2)毒品过量 摄入会损害随后的行为功能。 都是无条件的 行为（例如，运动活动）和精神运动表现（例如， 精细运动控制和计时行为）将在急性和 慢性口服药物自我管理，以及由此产生的档案相关 药物的血清浓度-时间曲线。 (3)结果 将口服自我给药与胃肠外给药进行比较 强迫。 目的是预测血清药代动力学 母体化合物及其活性成分的浓度-时间曲线 代谢物预测并发行为-时间曲线。 (4)研究 特别注意药物相互作用的行为和动力学， 同时使用和滥用合法和非法药物， 通常发生。

Request for ADAMHA Research Scientist Award. (1) Oral, schedule-induced (S-I) drug overindulgence, and chronic drug preference compared to vehicle, will be studied, especially as determined by the history of the environmental stimulus control (S/D) of preference, and current pharmacological factors. Drugs considered will be extended from cocaine to caffeine, midazolam and nicotine. Emphasis will be on tracing the situational sources initiating and maintaining drug abuse under conditions wherein pharmacologic impact is minimized, but functionally significant (oral route), while the environmental determination (S-I and S/D control) of the behavior maximized. This endeavors to clarify drug abuse initiation by an analysis of the gateways, both situational and pharmacologic, that make its acquisition probable. (2) Excessive drug intake can compromise ensuing behavioral functions. Both unconditioned behavior (e.g., locomotor activity) and psychomotor performance (e.g., fine-motor control and timing behaviors) will be measured after acute and chronic oral drug self-administration, and the resulting profiles related to a drug's measured serum concentration-time profile. (3) Results from oral self-administration will be compared to those of parenteral drug imposition. The aim is to predict whether serum pharmacokinetic concentration-time profiles of parent compounds and their active metabolites predict the concurrent behavior-time profiles. (4) Studies pay special attention to the behavior and kinetics of drug interactions, as concurrent use and abuse of substances, both licit and illicit, commonly occurs.