MEMORY PROCEDURES FOR DRUG ASSESSMENTS

描述：(申请人摘要) 将开发程序来测试药物对猴子视力的影响 和听觉列表-记忆。列表记忆过程与列表记忆过程相同 用于测试人类列表记忆。一群猴子将收到这两份名单中的任何一份 “旅行幻灯片”或环境声音，然后是一个单一的测试项目。 然后，他们就测试是否在名单中做出回应。 保留延迟测试内存。初步结果显示，视觉和 每个听觉记忆都由独立的记忆系统组成--这些系统 产生首要效果(对第一列表项有很好的记忆力，被认为是 与长期记忆相关)和近期效应(对最后一个列表的良好记忆力 被认为与短期记忆有关的物品)。听觉和视觉 内存在这些过程中有很大的不同，并限制了可能的 解释记忆的机制。拟议中的实验将具体说明 这些不同的记忆机制通过操纵保持间隔， 刺激呈现时间、刺激间间隔、项目重复、项目 添加到听觉和视觉记忆列表的开头或结尾，以及 主动干预和追溯性干预进程。了解记忆是如何 药物和药物滥用对记忆的作用机制和工作是必要的 任何有效的治疗方案。

DESCRIPTION: (Applicant's Abstract) Procedures will be developed to test the effects of drugs on monkey visual and auditory list-memory. The list-memory procedures are identical to ones used to test human list memory. Groups of monkeys will receive either lists of "travel slides" or environmental sounds, followed by a single test item. They then respond as to whether the test was or was not in the list. Retention delays test memory. Preliminary results show that visual and auditory memory are each composed of separate memory systems--systems that produce primacy effects (good memory for first list items, thought to be related to long-term memory) and recency effects (good memory for last list items, thought to be related to short-term memory). Auditory and visual memory are very different in these processes, and limits the possible mechanisms accounting for memory. The proposed experiments will specify these different memory mechanisms by manipulating-retention interval, stimulus presentation time, interstimulus interval, item repetition, items added to the beginning or end of auditory and visual memory lists, and proactive and retroactive interference processes. Understanding how memory works and the mechanisms of drugs and drug abuse on memory is necessary for any effective treatment regime.