MEMORY PROCEDURES FOR DRUG ASSESSMENTS

描述：（申请人摘要） 将开发程序来测试药物对猴视觉的影响 和听觉记忆 列表存储过程与 用来测试人类的列表记忆 一群猴子会收到两份名单 “旅行幻灯片”或环境声音，其次是一个单一的测试项目。 然后，他们会回答测试是否在列表中。 保留延迟测试内存。 初步结果显示，视觉和 听觉记忆是由独立的记忆系统组成的， 产生首因效应（对第一个列表项目的记忆良好，被认为是 与长期记忆有关）和近因效应（对最后一个列表的记忆良好 被认为与短期记忆有关）。 听觉和视觉 记忆在这些过程中是非常不同的，并限制了可能的 记忆机制 拟议的实验将说明 这些不同的记忆机制通过操纵保持间隔， 刺激呈现时间，刺激间隔，项目重复，项目 添加到听觉和视觉记忆列表的开头或结尾， 主动和追溯的干预过程。 了解记忆如何 作品和机制的药物和药物滥用对记忆是必要的 有效的治疗方案。

DESCRIPTION: (Applicant's Abstract) Procedures will be developed to test the effects of drugs on monkey visual and auditory list-memory. The list-memory procedures are identical to ones used to test human list memory. Groups of monkeys will receive either lists of "travel slides" or environmental sounds, followed by a single test item. They then respond as to whether the test was or was not in the list. Retention delays test memory. Preliminary results show that visual and auditory memory are each composed of separate memory systems--systems that produce primacy effects (good memory for first list items, thought to be related to long-term memory) and recency effects (good memory for last list items, thought to be related to short-term memory). Auditory and visual memory are very different in these processes, and limits the possible mechanisms accounting for memory. The proposed experiments will specify these different memory mechanisms by manipulating-retention interval, stimulus presentation time, interstimulus interval, item repetition, items added to the beginning or end of auditory and visual memory lists, and proactive and retroactive interference processes. Understanding how memory works and the mechanisms of drugs and drug abuse on memory is necessary for any effective treatment regime.