DEVELOPMENT OF BORDERLINE PERSONALITY DISORDER FEATURES

边缘性人格障碍特征的发展

• 批准号: 6185979
• 负责人: Timothy J Trull
• 金额: $ 19.92万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185979
• 关键词: adolescence (12-20); borderline personality disorder; child abuse; clinical research; disease /disorder etiology; gender difference; human subject; mental health epidemiology; parent offspring interaction; personality; university student; young adult human (21-34)

Borderline personality disorder (BPD) is a sever personality disorder that develops in early adulthood, and is characterized by a lack of control of anger, intense and frequent mood changes, impulsive acts, disturbed interpersonal relationships, and life-threatening behaviors. BPD is relatively prevalent in both clinical and nonclinical populations. Despite the prevalence of this condition, we know very little about how BPD features develop. Although a number of etiological factors have been proposed, studies exploring the etiological relevance of these factors suffer from a number of methodological limitations including: assessing subjects only after they have developed BPD, failing to assess gender effects, and employing cross-sectional designs. This application proposes a two-year prospective multi-cohort study of 500 18 year-old subjects that manifest varying degrees of BPD features; both genders will be equally represented. All subjects will be incoming freshman at the University of Missouri-Columbia, and subjects will complete a number of inventories and interviews at study intake (Time 1) and two-year follow-up (Time 2) that target the following constructs: BPD and other personality disorder features; parental psychopathology; and abuse experiences in childhood. The proposed study has five major aims: (1) to assess the correspondence between alternative measures of BPD features (self-report and interview); (2) to assess the relationship between personality traits and BPD features and determine whether the relations remain significant after partialling out variance in BPD scores accounted for by gender, parental psychopathology childhood physical and sexual abuse, and Axis l pathology; (3) to assess the two-year stability of scores on BPD measures; (4) To evaluate several models of how BPD features develop over time that include personality trail childhood abuse experiences, and parental psychopathology as moderators or mediators; and (5) to assess the relationship between Time 1 BPD symptom scores and negative outcome across a number of domains functioning, and to evaluate the potential moderating influence of personality traits, childhood abuse, and parental psychopathology on the relationship between Time 1 BPD scores and outcome two years later. By addressing these five aims, factors influencing future BPD pathology will be identified, more comprehensive etiological mode for BPD will be empirically evaluated, the level of dysfunction exhibited by syndromal and subsyndromal subjects will be assessed, and the predictive validity of BPD scores will be determined.

交界性人格障碍是一种严重的人格障碍。 在成年早期发展，其特点是缺乏对 愤怒，强烈而频繁的情绪变化，冲动的行为，不安 人际关系和危及生命的行为。BPD是 在临床和非临床人群中相对流行。尽管 这种情况的流行，我们对bpd是如何 功能会发展。尽管一些致病因素已经被 提出研究，探索这些因素的病因学相关性 受到一些方法的限制，包括：评估 受试者只有在患上BPD后才会被试，没有评估性别 效果，并采用横断面设计。此应用程序建议 一项对500名18岁受试者进行的为期两年的前瞻性多队列研究， 表现出不同程度的BPD特征；两性将平等 有代表性的。所有科目均为加州大学一年级新生 密苏里州-哥伦比亚州，受试者将完成一些清单和 在研究开始时的访谈(时间1)和两年的随访(时间2) 针对以下结构：BPD和其他人格障碍 特征；父母的精神病理学；以及童年时期的虐待经历。 建议的研究有五个主要目标：(1)评估 业务流程发展特点的其他衡量标准(自我报告和面谈)； (2)评估人格特质与BPD的关系 特征，并确定这些关系在 区分性别、父母在BPD得分中的差异 儿童时期的精神病理学、身体虐待和性虐待，以及L轴心的病理学； (3)评估BPD措施得分的两年稳定性；(4) 评估BPD功能如何随时间发展的几个模型，包括 人格痕迹儿童虐待经历和父母 作为主持人或调解人的精神病理学；以及(5)评估 时间-1桶/日症状评分与阴性结果的关系 一些领域的功能，并评估潜在的缓和 人格特征、童年虐待和父母的影响 时间-1bpd评分与预后关系的精神病理学研究 两年后。通过解决这五个目标，影响未来的因素 BPD的病理将被确定，更全面的病因模式 BPD将进行经验性评估， 将对综合征和亚综合征受试者进行评估，并预测 BPD分数的有效性将被确定。