DEVELOPMENT OF BORDERLINE PERSONALITY DISORDER FEATURES

边缘型人格障碍是一种严重的人格障碍， 在成年早期发展，其特点是缺乏对 愤怒，强烈和频繁的情绪变化，冲动行为，不安 人际关系和危及生命的行为。bpd是 在临床和非临床人群中相对普遍。尽管 这种情况的流行，我们对BPD如何知之甚少 特色发展。虽然一些病因因素已经被 提出，研究探索这些因素的病因学相关性， 受一些方法上的限制，包括： 受试者仅在发生BPD后，未能评估性别 影响，并采用横截面设计。本申请提出 一项对500名18岁受试者进行的两年前瞻性多队列研究， 表现出不同程度的BPD特征;两种性别将是平等的 代表。所有的科目将在大学新生 密苏里-哥伦比亚大学，受试者将完成一些清单， 研究入组（时间1）和两年随访（时间2）时的访谈， 针对以下结构：BPD和其他人格障碍 特征;父母的精神病理学;和童年的虐待经历。 本研究的主要目的有五：（1）评估 BPD特征的替代措施（自我报告和访谈）之间的差异; (2)评估人格特质和BPD之间的关系 特征，并确定关系是否在 BPD评分的偏除方差按性别、父母 精神病理学，儿童期身体虐待和性虐待，以及轴l病理学; (3)评估BPD指标评分的两年稳定性;（4） 评估BPD功能如何随时间发展的几个模型，包括 童年虐待经历的人格轨迹，以及父母 精神病理学作为调节剂或调解人;（5）评估 时间1 BPD症状评分与阴性结局之间的关系 一些领域的功能，并评估潜在的调节 人格特质、儿童期虐待和父母 时间1 BPD评分与结局之间关系的精神病理学 两年后。通过实现这五个目标，影响未来发展的因素 BPD病理将被确定，更全面的病因模式， BPD将根据经验进行评估，通过以下指标显示功能障碍的水平： 将评估综合征和亚综合征受试者， 将确定BPD评分的有效性。

Borderline personality disorder (BPD) is a sever personality disorder that develops in early adulthood, and is characterized by a lack of control of anger, intense and frequent mood changes, impulsive acts, disturbed interpersonal relationships, and life-threatening behaviors. BPD is relatively prevalent in both clinical and nonclinical populations. Despite the prevalence of this condition, we know very little about how BPD features develop. Although a number of etiological factors have been proposed, studies exploring the etiological relevance of these factors suffer from a number of methodological limitations including: assessing subjects only after they have developed BPD, failing to assess gender effects, and employing cross-sectional designs. This application proposes a two-year prospective multi-cohort study of 500 18 year-old subjects that manifest varying degrees of BPD features; both genders will be equally represented. All subjects will be incoming freshman at the University of Missouri-Columbia, and subjects will complete a number of inventories and interviews at study intake (Time 1) and two-year follow-up (Time 2) that target the following constructs: BPD and other personality disorder features; parental psychopathology; and abuse experiences in childhood. The proposed study has five major aims: (1) to assess the correspondence between alternative measures of BPD features (self-report and interview); (2) to assess the relationship between personality traits and BPD features and determine whether the relations remain significant after partialling out variance in BPD scores accounted for by gender, parental psychopathology childhood physical and sexual abuse, and Axis l pathology; (3) to assess the two-year stability of scores on BPD measures; (4) To evaluate several models of how BPD features develop over time that include personality trail childhood abuse experiences, and parental psychopathology as moderators or mediators; and (5) to assess the relationship between Time 1 BPD symptom scores and negative outcome across a number of domains functioning, and to evaluate the potential moderating influence of personality traits, childhood abuse, and parental psychopathology on the relationship between Time 1 BPD scores and outcome two years later. By addressing these five aims, factors influencing future BPD pathology will be identified, more comprehensive etiological mode for BPD will be empirically evaluated, the level of dysfunction exhibited by syndromal and subsyndromal subjects will be assessed, and the predictive validity of BPD scores will be determined.