FASEB RESEARCH CONFERENCE ON BIOLOGICAL METHYLATION

FASEB 生物甲基化研究会议

• 批准号: 2883854
• 负责人: JUDITH K CHRISTMAN
• 金额: $ 0.9万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-16 至 2000-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2883854
• 关键词: DNA methylation; enzyme mechanism; enzyme structure; meeting /conference /symposium; methylation; methyltransferase; nucleic acid sequence; protein structure function; systematic biology; travel; workshop

This application is for partial funding for a conference called "Biological Methylation" to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB) at the Vermont Academy from July 16-July 22, 1999. This will be the fourth biennial FASEB conference on biological methylation. These meetings are virtually unique in their focus on the full range of AdoMet-dependent methyltransferases. Analysis of genomic sequences from archaea, eubacteria, fungi plants and animals suggests that a large fraction of all genes specify AdoMet dependent methyltransferases, yet it only a few years since it has been shown that most of these enzymes share a common core structure despite undetectable sequence identity. Thus, the meeting program is designed to promote a productive dialogue between scientists who study methyltransferase structure, function and regulation and those concentrating on biological importance of the effects of enzymatic methylation on a myriad substrates ranging from DNA, RNA and proteins to small organic molecules and metals. The conference will feature five speaker sessions (21 speakers), continual display of posters in a session lasting four days, and a series of 14 workshops on cutting-edge or controversial topics in the field that will include at least 30 min for open discussion. In addition, two workshops will be devoted to presentation and discussion of posters selected by the attendees as examples of the most exciting new work. This will be a new feature of this conference and should be a particularly good forum for younger investigators as well as new comers to the field to highlight their research findings. This series of conferences on biological methylation is a major meeting ground for discussion of DNA methylation and the DNA methylation society will continue to provide partial support for the registration fees of presenters of posters selected by its Board of Directors for special merit. Clinical and environmental applications of biological methylation, as well as basic research, will be highlighted at this conference. The ultimate goal of the organizers is to make sure that all participants have an equal opportunity to have their current research presented and discussed in a meaningful way, while continuing the tradition of providing expert overviews of new developments in important areas.

本申请是为1999年7月16日至7月22日在佛蒙特学院举行的由美国实验生物学学会联合会（FASEB）主办的“生物甲基化”会议提供部分资金。这将是第四届两年一度的FASEB生物甲基化会议。这些会议实际上是独一无二的，因为他们专注于adomet依赖性甲基转移酶的全范围。对古细菌、真细菌、真菌、植物和动物基因组序列的分析表明，所有基因中的很大一部分都指定AdoMet依赖的甲基转移酶，然而，仅仅几年前，人们就发现，尽管无法检测到序列的同一性，但大多数这些酶具有共同的核心结构。因此，会议计划旨在促进研究甲基转移酶结构，功能和调节的科学家与专注于酶甲基化对无数底物（从DNA， RNA和蛋白质到小有机分子和金属）影响的生物学重要性的科学家之间进行富有成效的对话。会议将包括5场演讲（21名演讲者），在为期4天的会议中持续展示海报，以及14场关于该领域前沿或争议话题的系列研讨会，其中包括至少30分钟的公开讨论。此外，两个工作坊将专门介绍和讨论由与会者选出的最令人兴奋的新作品的海报。这将是这次会议的一个新特点，应该是一个特别好的论坛，为年轻的研究者和新来者的领域，以突出他们的研究成果。这一系列关于生物甲基化的会议是讨论DNA甲基化的主要会议场所，DNA甲基化学会将继续为其董事会选出的特别优秀海报的演讲者的注册费提供部分支持。本次会议将重点讨论生物甲基化的临床和环境应用以及基础研究。组织者的最终目标是确保所有参与者都有平等的机会以有意义的方式展示和讨论他们当前的研究，同时继续提供重要领域新发展的专家概述的传统。