FASEB RESEARCH CONFERENCE ON BIOLOGICAL METHYLATION

FASEB 生物甲基化研究会议

• 批准号: 2883854
• 负责人: JUDITH K CHRISTMAN
• 金额: $ 0.9万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-16 至 2000-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2883854
• 关键词: DNA methylation; enzyme mechanism; enzyme structure; meeting /conference /symposium; methylation; methyltransferase; nucleic acid sequence; protein structure function; systematic biology; travel; workshop

This application is for partial funding for a conference called "Biological Methylation" to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB) at the Vermont Academy from July 16-July 22, 1999. This will be the fourth biennial FASEB conference on biological methylation. These meetings are virtually unique in their focus on the full range of AdoMet-dependent methyltransferases. Analysis of genomic sequences from archaea, eubacteria, fungi plants and animals suggests that a large fraction of all genes specify AdoMet dependent methyltransferases, yet it only a few years since it has been shown that most of these enzymes share a common core structure despite undetectable sequence identity. Thus, the meeting program is designed to promote a productive dialogue between scientists who study methyltransferase structure, function and regulation and those concentrating on biological importance of the effects of enzymatic methylation on a myriad substrates ranging from DNA, RNA and proteins to small organic molecules and metals. The conference will feature five speaker sessions (21 speakers), continual display of posters in a session lasting four days, and a series of 14 workshops on cutting-edge or controversial topics in the field that will include at least 30 min for open discussion. In addition, two workshops will be devoted to presentation and discussion of posters selected by the attendees as examples of the most exciting new work. This will be a new feature of this conference and should be a particularly good forum for younger investigators as well as new comers to the field to highlight their research findings. This series of conferences on biological methylation is a major meeting ground for discussion of DNA methylation and the DNA methylation society will continue to provide partial support for the registration fees of presenters of posters selected by its Board of Directors for special merit. Clinical and environmental applications of biological methylation, as well as basic research, will be highlighted at this conference. The ultimate goal of the organizers is to make sure that all participants have an equal opportunity to have their current research presented and discussed in a meaningful way, while continuing the tradition of providing expert overviews of new developments in important areas.

本申请为名为“生物甲基化”的会议提供部分资助，该会议将于 1999 年 7 月 16 日至 7 月 22 日在美国实验生物学会联合会 (FASEB) 的主持下在佛蒙特学院举行。这将是第四届双年度 FASEB 生物甲基化会议。这些会议实际上是独一无二的，因为它们关注全系列 AdoMet 依赖性甲基转移酶。 对古细菌、真细菌、真菌、植物和动物的基因组序列的分析表明，所有基因中的很大一部分都指定了 AdoMet 依赖性甲基转移酶，但仅仅几年前，就表明这些酶中的大多数具有共同的核心结构，尽管无法检测到序列同一性。 因此，会议议程旨在促进研究甲基转移酶结构、功能和调节的科学家与专注于酶甲基化对无数底物（从 DNA、RNA 和蛋白质到小有机分子和金属）影响的生物学重要性的科学家之间的富有成效的对话。 会议将包括五场演讲者会议（21 位演讲者）、持续四天的会议中连续展示海报，以及一系列关于该领域前沿或有争议话题的 14 场研讨会，其中包括至少 30 分钟的公开讨论。 此外，两个研讨会将专门展示和讨论与会者选出的海报作为最令人兴奋的新作品的例子。 这将是本次会议的一个新特点，对于年轻的研究人员以及该领域的新人来说应该是一个特别好的论坛，以强调他们的研究成果。 本次生物甲基化系列会议是讨论DNA甲基化的重要会议场所，DNA甲基化学会将继续为理事会选出的有特绩的海报展示者的注册费提供部分支持。 本次会议将重点关注生物甲基化的临床和环境应用以及基础研究。 组织者的最终目标是确保所有参与者都有平等的机会以有意义的方式展示和讨论他们当前的研究，同时延续对重要领域的新发展提供专家概述的传统。