WOUND HEALING RESPONSES TO TI IMPLANT SURFACES

牙科植入物在临床实践中广泛使用，但没有 关于材料选择、设计或 这些器件应采用的表面特性。 我们实验室的初步信息表明， 商业植入物变化很大， 反应 此应用程序的目标是为申请人提供 掌握了解决这些生物材料问题所需的技能 通过表征材料对生物学的影响进行研究 应答 这些实验是专门设计来研究 诸如金属选择形貌、氧化物 结构和组成，以及表面电荷和能量， 表面表征技术，包括SEM/EDAX、XPS、AES和 接触角测量 这些条件对 基本的生物过程，如基质沉积和细胞 附着、扩散和增殖将解决这样一个假设， 植入物表面的改性决定了生物接受性AD， 从而长期组织相容性。 比表 在确定合适的基底时很重要的特性 生物可接受性将得到确认。 本研究 重要的临床意义在于它将有助于定义一个模型 具有最佳组织反应植入物表面。 导师 和具有细胞生物学相关领域专业知识的顾问 和材料表面科学已经选定，并取得了丰硕的成果。 研究环境的选择，以协助候选人在他的长期 更好地了解材料对生物学的影响 系统.

Dental implants are widely used in clinical practice, yet there are no established criteria regarding the choice of material, design, or surface characteristics which should be employed for these devices. Preliminary information from our laboratory suggests that the surface of commercial implants varies widely and influences the biological response. The goals of this application are to provide the applicant with the skills necessary to approach these problems of biomaterials research by characterizing the effects of materials on the biological responses. The experiments proposed are specifically designed to study a number of variables such as metal selection topography, oxide structure and composition, and surface charge and energy by using surface characterization techniques, including SEM/EDAX, XPS, AES, and contact angle measurements. The effects of these conditions on fundamental biological processes such as matrix deposition and cellular attachment, spreading and proliferation will address the hypothesis that modifications of the implant surface determine biological acceptance ad, thereby long term tissue compatibility. Specific surface characteristics which are important in determining a suitable substratum for biological acceptability will be ascertained. This research has important clinical implications in that it will help define a model implant surface to which there is an optimum tissue response. Mentors and consultants with expertise in the appropriate areas of cell biology and materials surface science have been selected, and a productive research environment chosen, so as to assist the candidate in his long term goal to better understand the effects of material on biological systems.