WOUND HEALING RESPONSES TO TI IMPLANT SURFACES

TI 植入物表面的伤口愈合反应

• 批准号: 3072180
• 负责人: JOHN C. KELLER
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3072180
• 关键词: alkaline phosphatase; alloys; biomaterial compatibility; biomaterial evaluation; collagen; connective tissue; dental adhesive /sealant; dental implants; enzyme linked immunosorbent assay; extracellular matrix; fibroblasts; gene expression; laboratory rat; metal dental material; monoclonal antibody; osteocalcin; osteonectin; oxides; periodontium; surface property; titanium; wound healing

Dental implants are widely used in clinical practice, yet there are no established criteria regarding the choice of material, design, or surface characteristics which should be employed for these devices. Preliminary information from our laboratory suggests that the surface of commercial implants varies widely and influences the biological response. The goals of this application are to provide the applicant with the skills necessary to approach these problems of biomaterials research by characterizing the effects of materials on the biological responses. The experiments proposed are specifically designed to study a number of variables such as metal selection topography, oxide structure and composition, and surface charge and energy by using surface characterization techniques, including SEM/EDAX, XPS, AES, and contact angle measurements. The effects of these conditions on fundamental biological processes such as matrix deposition and cellular attachment, spreading and proliferation will address the hypothesis that modifications of the implant surface determine biological acceptance ad, thereby long term tissue compatibility. Specific surface characteristics which are important in determining a suitable substratum for biological acceptability will be ascertained. This research has important clinical implications in that it will help define a model implant surface to which there is an optimum tissue response. Mentors and consultants with expertise in the appropriate areas of cell biology and materials surface science have been selected, and a productive research environment chosen, so as to assist the candidate in his long term goal to better understand the effects of material on biological systems.

种植牙在临床上应用广泛，但目前尚无种植牙技术。 制定了有关材料选择、设计或 这些设备应采用的表面特性。 我们实验室的初步信息表明，表面 商业植入物差异很大并影响生物学 回复。 本申请的目标是为申请人提供 拥有解决这些生物材料问题所需的技能 通过表征材料对生物的影响进行研究 回应。 所提出的实验是专门设计来研究 许多变量，例如金属选择形貌、氧化物 结构和组成，以及表面电荷和能量 表面表征技术，包括 SEM/EDAX、XPS、AES 和 接触角测量。 这些条件的影响 基本的生物过程，例如基质沉积和细胞 附着、传播和增殖将解决以下假设： 植入物表面的修饰决定了生物可接受性， 从而实现长期的组织相容性。 比表面积 对于确定合适的基质很重要的特征 将确定生物学可接受性。 这项研究有 重要的临床意义，因为它将有助于定义模型 具有最佳组织反应的种植体表面。 导师 以及在细胞生物学相关领域具有专业知识的顾问 和材料表面科学已被选择，并且富有成效 选择的研究环境，以帮助候选人长期从事研究工作 术语目标是更好地理解材料对生物的影响 系统。