WOUND HEALING RESPONSES TO TI IMPLANT SURFACES

牙种植体在临床上得到了广泛的应用，但目前还没有 关于选择材料、设计或 这些器件应采用的表面特性。 来自我们实验室的初步信息表明， 商业植入物变化很大，并影响生物 回应。本申请的目的是为申请者提供 具备解决这些生物材料问题所需的技能 通过表征材料对生物的影响进行研究 回应。提出的实验是专门设计用来研究 一系列变量，如金属选择、地形、氧化物 结构和组成，以及表面电荷和能量通过使用 表面表征技术，包括SEM/EDAX、XPS、AES和 接触角测量。这些条件对 基本的生物过程，如基质沉积和细胞 依附、扩散和扩散将解决以下假设 植入物表面的修改决定了生物接受度AD， 从而实现长期的组织相容性。比表面 在确定合适的基质时非常重要的特性 在生物学上的可接受性将被确定。这项研究已经 重要的临床意义在于它将有助于定义一种模型 组织反应最佳的植入物表面。导师 以及在适当的细胞生物学领域拥有专业知识的顾问 和材料表面科学都已入选，并富有成效 选择研究环境，以帮助应聘者在他的长期工作中 学期目标：更好地理解材料对生物的影响 系统。

Dental implants are widely used in clinical practice, yet there are no established criteria regarding the choice of material, design, or surface characteristics which should be employed for these devices. Preliminary information from our laboratory suggests that the surface of commercial implants varies widely and influences the biological response. The goals of this application are to provide the applicant with the skills necessary to approach these problems of biomaterials research by characterizing the effects of materials on the biological responses. The experiments proposed are specifically designed to study a number of variables such as metal selection topography, oxide structure and composition, and surface charge and energy by using surface characterization techniques, including SEM/EDAX, XPS, AES, and contact angle measurements. The effects of these conditions on fundamental biological processes such as matrix deposition and cellular attachment, spreading and proliferation will address the hypothesis that modifications of the implant surface determine biological acceptance ad, thereby long term tissue compatibility. Specific surface characteristics which are important in determining a suitable substratum for biological acceptability will be ascertained. This research has important clinical implications in that it will help define a model implant surface to which there is an optimum tissue response. Mentors and consultants with expertise in the appropriate areas of cell biology and materials surface science have been selected, and a productive research environment chosen, so as to assist the candidate in his long term goal to better understand the effects of material on biological systems.