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TOXICOLOGIC EFFECTS OF AIR POLLUTANTS ON LUNG DEFENSE

TOXICOLOGIC EFFECTS OF AIR POLLUTANTS ON LUNG DEFENSE
空气污染物对肺部防御的毒理学影响
批准号：
3072662
负责人：
Richard B Schlesinger
金额：
$5.34万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
项目状态：
已结题
起止时间：
1983-07-01 至 1988-06-30
来源：
https://reporter.nih.gov/project-details/3072662
关键词：
aerosols air pollution alveolar macrophages biological fluid transport bronchial mucus bronchomotion cell adhesion cell motility environmental toxicology inhalation drug administration lung phagocytosis pollutant interaction pollution related respiratory disorder radiotracer respiratory airflow measurement respiratory airway clearance respiratory airway pressure respiratory epithelium respiratory function respiratory gas analyzer scintillation counter toxin metabolism

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中文摘要
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英文摘要
This project involves examination of the toxicologic effects of single and repeated exposures to sulfuric acid mist, nitrogen dioxide, or ozone upon nonspecific defense mechanisms of the lung, using the rabbit as an animal model. The basic mechanisms examined are reflex bronchoconstriction, mucociliary clearance from the tracheobronchial tree, and alveolar macrophage-mediated clearance from the repiratory region. Clearance is studied in unsedated animals using radioactively tagged tracer aerosols. Specific functional aspects of macrophages will be examined in vitro following in vivo exposures. In addition, histological analyses of lung tissue will be performed. Results of the macrophage and tissue assays will be related to overall clearance effectiveness. This study will provide information on the role of three major ambient air pollutants in altering essential lung defenses; such changes may be early stages in the progression towards chronic obstructive lung disease.
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