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EFFECTS OF N02 AND 03 ON LUNG CLEARANCE

EFFECTS OF N02 AND 03 ON LUNG CLEARANCE
N02 和 03 对肺间隙的影响
批准号：
3250383
负责人：
Richard B Schlesinger
金额：
$10.84万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
项目状态：
已结题
起止时间：
1983-07-01 至 1987-03-31
来源：
https://reporter.nih.gov/project-details/3250383
关键词：
aerosols air pollution alveolar macrophages cell adhesion cell motility diagnostic respiratory lavage emphysema environmental toxicology flow cytometry inhalation drug administration lung phagocytosis pollution related respiratory disorder radiotracer respiratory airflow disorder respiratory airflow measurement respiratory airway clearance respiratory airway pressure scintillation counter technetium

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中文摘要
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英文摘要
This project involves examination fo the effects of single and repeated exposures to NO2 and O3, two important ambient air pollutants, upon clearance defense mechanisms of the lung, using the rabbit as the animal model. The mechanisms are mucociliary transport in the tracheobronchial tree and macrophage-mediated clearance from the alveolar region. Clearance is studied in unsedated animals using radioactively tagged tracer aerosols. Effects of NO2 and O3 upon specific functional aspects of alveolar macrophages will also be examined and related to measured overall clearance patterns. This project will provide information on the role of NO2 and O3 in producing clearance dysfunction, which may be an early stage in the pathogenesis of chronic obstructive lung disease.
期刊论文(11)
专著(0)
科研奖励(0)
会议论文
Intermittent inhalation of nitrogen dioxide: effects on rabbit alveolar macrophages.
间歇性吸入二氧化氮：对兔肺泡巨噬细胞的影响。
DOI： 10.1080/15287398709531007
发表时间： 1987
期刊： Journal of toxicology and environmental health
影响因子： --
作者： [Schlesinger,RB]
通讯作者： Schlesinger,RB
Intermittent exposures to mixed atmospheres of nitrogen dioxide and sulfuric acid: effect on particle clearance from the respiratory region of rabbit lungs.
间歇性暴露于二氧化氮和硫酸的混合气氛：对兔肺呼吸区域颗粒清除的影响。
DOI： 10.1016/0300-483x(87)90032-1
发表时间： 1987
期刊： Toxicology
影响因子： 4.5
作者： [Schlesinger,RB, Gearhart,JM]
通讯作者： Gearhart,JM
Effect of repeated exposures to nitrogen dioxide and sulfuric acid mist alone or in combination on mucociliary clearance from the lungs of rabbits.
单独或组合重复暴露于二氧化氮和硫酸雾对兔子肺部粘液纤毛清除的影响。
DOI： 10.1016/s0013-9351(87)80238-4
发表时间： 1987
期刊： Environmental research
影响因子： 8.3
作者： [Schlesinger,RB, Driscoll,KE, Vollmuth,TA]
通讯作者： Vollmuth,TA
Effects of inhaled acids on respiratory tract defense mechanisms.
吸入酸对呼吸道防御机制的影响。
DOI： 10.1289/ehp.856325
发表时间： 1985
期刊： Environmental health perspectives
影响因子： 10.4
作者： [Schlesinger,RB]
通讯作者： Schlesinger,RB
共 10 条
    TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGY
    TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGY
    ROLE OF CYTOKINE METABOLISM IN OZONE IMMUNOTOXICITY
    O3 AND MODULATING CR TOXICITY AND THE LUNG
    海外基金