LUNG CLEARANCE DURING REPEATED EXPOSURES TO H2SO4 & O3

反复暴露于 H2SO4 期间的肺间隙

• 批准号: 3252622
• 负责人: Richard B Schlesinger
• 金额: $ 16.28万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3252622
• 关键词: acids; alveolar macrophages; histology; lung alveolus; lung disorder; lung lavage; neutrophil; ozone; pollution related respiratory disorder; proteoglycan; radiotracer; respiratory airway clearance; respiratory epithelium; secretion; sulfates

This project examines the effects of intermittent (2/hd, 5/d wk) exposures to O3 and H2SO4 upon clearance defense mechanisms of the lung, using the rabbit as the animal model. Tracheobronchial mucociliary clearance, alveolar clearance and functional properties of macrophages obtained by lavage from exposed animals will be assessed. In addition, permeability of bronchila mucosa and alveolar epithelium will be examined, as will histology of lung tissue at selected times during the exposure series. Exposures will last up to 12 mo., with groups of rabbits sacrificed at 4, 8, 12 and 15 mo. The latter provides for a recovery period to examine resolution of effects. Clearance is studied in unsedated animals using radioactively tagged tracer aerosols. The results of this project will help in elucidation of the role that alteration in clearance function may have in pathogenesis of chronic lung disease, and the temporal relationship between changes in a number of factors which could affect defense functions.

这个项目考察了间歇性(2/HD，5/d wk)的影响 O_3和H_2SO_4暴露对清除防御机制的影响 取肺组织，以兔为动物模型。 气管、支气管粘液纤毛清除、肺泡清除和 大鼠巨噬细胞灌洗后的功能特性 将对暴露的动物进行评估。此外，通透性 将检查支气管粘膜和肺泡上皮，以及 暴露期间选定时间的肺组织的组织学 系列片。暴露时间将长达12个月，由一群兔子组成 分别于4、8、12、15个月处死。后者规定了一个 恢复期，以检查效果的解决。净空是 使用放射性标记示踪剂在未服用镇静剂的动物中进行研究 气雾剂。这一项目的结果将有助于阐明 通关功能的改变可能在 慢性肺病的发病机制，以及颞叶 一些因素的变化之间的关系，这些因素可能 影响防御功能。