DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING

隔膜对呼吸训练的适应

• 批准号: 3082546
• 负责人: DAVID J PREZANT
• 金额: $ 6.38万
• 依托单位: MONTEFIORE MEDICAL CENTER (BRONX, NY)
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3082546
• 关键词: artificial respiration; atrophy; catecholamines; diaphragm; dobutamine; exercise; glucose metabolism; insulin; laboratory rat; mitochondria; muscle contraction; muscle function; muscle hypertrophy; muscle relaxation; muscle tension; oxygen consumption; oxygen microelectrode; pulmonary respiration

Respiratory muscle fatigue and mechanical ventilator dependency contribute significantly to the morbidity and mortality of patients suffereing from chronic pulmonary disease. The diaphragm is the principal muscle of inspiration and the only skeletal muscle considered to be a vital organ. Yet, the adaptive capability of the diaphragm to varying amounts of respiratory work has received little investigative attention. The aim of this project will be to define the biochemical characteristics and mechanisms by which the rat diaphragm adapts to overuse and disuse; to determine if the adaptation to disuse is preventable or reversible and to gain new insight into the biochemical limitations responsible for respiratory muscle fatigue and failure. This will be accomplished employing experimental models already in use by this applicant. Specifically, surgically implanted tracheal resistors are used to study the diaphragm's response to endurance training and prolonged mechanical ventilation is used to study the diaphragm's response to disuse. The adaptive response of the diaphragm will be analyzed using measurements of fiber type, contractility and endurance as well as functional biochemical indices of whole muscle and mitochondria oxidative capacity, Preliminary data indicates that rat diaphragm muscle does adapt to resistance training with hypertrophy and adapts to mechanical ventilation with atrophy.

呼吸肌疲劳和机械呼吸机依赖