A modular toolbox of novel polymer nanorods for better tissue penetration

新型聚合物纳米棒的模块化工具箱，可实现更好的组织渗透

• 批准号: DE180100007
• 负责人: A/Prof Markus Muellner
• 金额: $ 27.05万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100007
• 关键词: modular; toolbox; novel; polymer; nanorods

This project aims to establish a suite of design parameters to provide new avenues for understanding and manipulating tissue infiltration by future therapeutic nanoparticles. The project expects to develop an innovative technology that allows independent control over nanoparticle geometry, functionality, and mechanical and surface properties. This level of control over the synthesis of polymer nanoparticles with distinct physicochemical properties will enable precise adjustment and investigation of discrete particle properties. The project will reshape fundamental knowledge of nanoparticle design by demonstrating the centrality of particle shape, stiffness, and heterogeneity. The outcomes will significantly advance the science of polymer nanoparticle synthesis control, aiding the development of novel and more effective polymer nano-therapeutics.

该项目旨在建立一套设计参数，为理解和操纵未来治疗性纳米颗粒的组织浸润提供新的途径。该项目希望开发一种创新技术，可以独立控制纳米颗粒的几何形状、功能、机械和表面特性。这种对具有不同物理化学性质的聚合物纳米颗粒合成的控制水平将使精确调整和研究离散颗粒性质成为可能。该项目将通过展示颗粒形状、刚度和非均质性的中心性来重塑纳米颗粒设计的基础知识。这些结果将显著推动聚合物纳米颗粒合成控制科学，帮助开发新的和更有效的聚合物纳米治疗方法。