Biomimetic hydrogels

仿生水凝胶

• 批准号: DP220100452
• 负责人: A/Prof Markus Muellner
• 金额: $ 32.56万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-10-21 至 2025-10-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220100452
• 关键词: Biomimetic; hydrogels

Hydrogels are promising materials to repair and regenerate damaged tissues, but their weak mechanical properties limit their applications. This project aims to develop hydrogels with better mechanical properties by mimicking the way natural tissues, such as cartilage, work. Specifically, we aim to develop a new class of hydrogels by adding molecular polymer brushes to traditional materials. We will design the hydrogels with long-term stability and render them suitable as viable hosts for chondrocytes. Through this project, we will grow fundamental knowledge in polymer chemistry and tissue engineering, and pave the way for new technologies to repair damaged joints and tissues.

水凝胶是修复和再生受损组织的有前途的材料，但其较弱的机械性能限制了其应用。该项目旨在通过模仿软骨等天然组织的工作方式，开发具有更好机械性能的水凝胶。具体来说，我们的目标是通过在传统材料中添加分子聚合物刷来开发一类新的水凝胶。我们将设计具有长期稳定性的水凝胶，并使其适合作为软骨细胞的可行宿主。通过这个项目，我们将增长聚合物化学和组织工程的基础知识，并为修复受损关节和组织的新技术铺平道路。