CENTRAL NERVOUS SYSTEM SEQUELAE OF CONGENITAL CMV

该项目中的提案代表了我们的直接延伸 多年来一直试图定义的研究 巨细胞病毒感染引起的一系列疾病 生命早期（宫内和围产期感染）。 由于其 当胎儿和小婴儿获得时，其慢性程度惊人， CMV 感染不仅有可能导致严重的 急性多器官系统疾病而且范围广泛（深刻 和微妙）中枢神经系统和知觉缺陷， 可以想象，这可能会持续多年。 我们目前的建议侧重于最先进技术的应用 增加我们对进化的理解的技术 先天性巨细胞病毒感染引起的中枢神经系统疾病。 我们将完善我们的 频率、范围和决定因素的知识 通过纵向多学科治疗神经认知缺陷 对明确定义的患者群体进行的研究。 我们也会尝试 使用以下方法识别婴儿早期中枢神经系统的 CMV 感染 病毒学、免疫学和复杂的成像技术。 早期识别中枢神经系统受累可能代表 重要的进展，对于提供准确的预测至关重要， 检测进行性中枢神经系统疾病，并可能用于识别 可能受益于抗病毒治疗的患者。

The proposals in this project represent direct extensions of our research that for a number of years has sought to define the spectrum of disease which results from acquiring CMV infection in early life (intrauterine and perinatal infection). Because of its striking chronicity when acquired by the fetus and young infant, CMV infection has a potential for producing not only severe acute multi-organ system disease but also a wide range (profound and subtle) of central nervous system and perceptual defects, which conceivably could be progressive for a number of years. Our current proposal is focused on application of state of the art techniques to increasing our understanding of the evolution of CNS disease in congenital CMV infection. We will refine our knowledge of the frequency, range and determinants of neurocognitive deficits through longitudinal multidisciplinary studies in well defined patient populations. We will also attempt to identify CMV infection of the CNS in early infancy using virologic, immunologic and sophisticated imaging techniques. Early identification of CNS involvement could represent an important advance, essential for providing an accurate prognosis, detecting progressive CNS disease and perhaps for identifying patients who could potentially benefit from antiviral therapy.