CENTRAL NERVOUS SYSTEM SEQUELAE OF CONGENITAL CMV

本项目中的提案代表了我们的 多年来一直试图定义 CMV感染引起的疾病谱 在生命早期（宫内和围产期感染）。 由于其 当胎儿和幼儿获得时具有显著的慢性性， CMV感染不仅有可能产生严重的 急性多器官系统疾病，而且范围广泛（深刻 和微妙）的中枢神经系统和知觉缺陷， 可以想象，这可能会持续数年。 我们目前的建议侧重于应用最先进的技术 技术来增加我们对进化的理解， 先天性巨细胞病毒感染引起的中枢神经系统疾病 我们将完善我们的 频率、范围和决定因素的知识 神经认知缺陷通过纵向多学科 在明确定义的患者人群中进行的研究。 我们还将尝试 为了确定婴儿早期CNS的CMV感染， 病毒学、免疫学和复杂的成像技术。 早期发现中枢神经系统受累可能代表 对于提供准确预后至关重要的重要进展， 检测进行性CNS疾病， 可能从抗病毒治疗中获益的患者。

The proposals in this project represent direct extensions of our research that for a number of years has sought to define the spectrum of disease which results from acquiring CMV infection in early life (intrauterine and perinatal infection). Because of its striking chronicity when acquired by the fetus and young infant, CMV infection has a potential for producing not only severe acute multi-organ system disease but also a wide range (profound and subtle) of central nervous system and perceptual defects, which conceivably could be progressive for a number of years. Our current proposal is focused on application of state of the art techniques to increasing our understanding of the evolution of CNS disease in congenital CMV infection. We will refine our knowledge of the frequency, range and determinants of neurocognitive deficits through longitudinal multidisciplinary studies in well defined patient populations. We will also attempt to identify CMV infection of the CNS in early infancy using virologic, immunologic and sophisticated imaging techniques. Early identification of CNS involvement could represent an important advance, essential for providing an accurate prognosis, detecting progressive CNS disease and perhaps for identifying patients who could potentially benefit from antiviral therapy.