CENTRAL NERVOUS SYSTEM SEQUELAE OF CONGENITAL CMV

先天性巨细胞病毒的中枢神经系统后遗症

• 批准号: 3857356
• 负责人: ROBERT F PASS
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3857356
• 关键词: Herpesviridae disease; behavior test; brain mapping; central nervous system disorders; cerebrospinal fluid; child (0-11); child physical development; child psychology; chorioretinitis; communicable disease transmission; computed axial tomography; congenital infection; congenital nervous system disorder; cytomegalovirus; enzyme linked immunosorbent assay; female; genetic manipulation; gestational age; hearing disorders; human fetus tissue; human pregnant subject; human subject; immunofluorescence technique; infant human (0-1 year); learning disorders; longitudinal human study; magnetic resonance imaging; monoclonal antibody; neuropsychological tests; nucleic acid probes; perinatal; pregnancy immunology; prognosis; psychological tests; psychometrics; puerperal infection; relapse /recurrence; virulence; virus antigen; virus cytopathogenic effect; virus infection mechanism

The proposals in this project represent direct extensions of our research that for a number of years has sought to define the spectrum of disease which results from acquiring CMV infection in early life (intrauterine and perinatal infection). Because of its striking chronicity when acquired by the fetus and young infant, CMV infection has a potential for producing not only severe acute multi-organ system disease but also a wide range (profound and subtle) of central nervous system and perceptual defects, which conceivably could be progressive for a number of years. Our current proposal is focused on application of state of the art techniques to increasing our understanding of the evolution of CNS disease in congenital CMV infection. We will refine our knowledge of the frequency, range and determinants of neurocognitive deficits through longitudinal multidisciplinary studies in well defined patient populations. We will also attempt to identify CMV infection of the CNS in early infancy using virologic, immunologic and sophisticated imaging techniques. Early identification of CNS involvement could represent an important advance, essential for providing an accurate prognosis, detecting progressive CNS disease and perhaps for identifying patients who could potentially benefit from antiviral therapy.

该项目中的建议代表了我们 多年来一直试图定义 感染巨细胞病毒引起的疾病谱 在生命早期(宫内和围产期感染)。因为它的 当胎儿和婴儿获得时，显著的慢性化， 巨细胞病毒感染不仅有可能导致严重的 急性多脏器系统疾病还涉及范围广(深 和微妙的)中枢神经系统和知觉缺陷， 可以想象的是，这种情况可能会在未来几年内逐步发展。 我们目前的建议集中在最新技术的应用上 增加我们对生物进化过程的理解的技术 先天性巨细胞病毒感染中的中枢神经系统疾病。我们将完善我们的 知识的频率，范围和决定因素 纵向多学科的神经认知缺陷 在明确定义的患者群体中进行研究。我们还将尝试 婴儿早期中枢神经系统巨细胞病毒感染的检测 病毒学、免疫学和复杂的成像技术。 早期发现中枢神经系统的参与可能是一种 重要的进展，对提供准确的预测至关重要， 检测进行性中枢神经系统疾病并可能用于识别 可能从抗病毒治疗中受益的患者。