SOURCES OF MATERNAL AND FETAL CMV INFECTION

母体和胎儿巨细胞病毒感染的来源

• 批准号: 3842588
• 负责人: ROBERT F PASS
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3842588
• 关键词: Herpesviridae disease; adolescence (12-20); age at pregnancy; child (0-11); communicable disease transmission; congenital infection; cytomegalovirus; enzyme linked immunosorbent assay; epidemiology; female; gel electrophoresis; genetic mapping; human pregnant subject; human subject; longitudinal human study; microorganism culture; molecular cloning; newborn human (0-6 weeks); perinatal; pregnancy immunology; pregnancy infection; relapse /recurrence; serology /serodiagnosis; sex behavior; sexually transmitted diseases; virus DNA; virus genetics; virus infection mechanism

This proposal will test the hypothesis that young children are an important source of CMV infection for their mothers and that maternal infection acquired from a child by a pregnant women can result in fetal infection. Our extensive work in CMV epidemiology, particularly recent studies of transmission of CMV among children and to their parents, coupled with knowledge that virtually nothing is known about sources of maternal CMV infection , led to formulation of this hypothesis and our plan for addressing it. Recognizing existing epidemiologic data that supports a role for sexual transmission, we also plan to evaluate the potential importance of this mechanism of maternal and fetal infection through a study of mothers of children with congenital CMV infection, utilizing a case-control design, and through longitudinal study of sexually active adolescents.

这一提议将检验一个假设，即幼儿是一个 是母亲感染巨细胞病毒的重要来源， 孕妇从孩子那里获得的母体感染 会导致胎儿感染 我们在CMV领域的广泛工作 流行病学，特别是最近对CMV传播的研究 在儿童及其父母中，再加上知识 事实上对母体CMV的来源一无所知 感染，导致制定这一假设和我们的计划， 认识到现有的流行病学数据， 支持性传播的作用，我们还计划评估 这一机制的潜在重要性， 通过对患有胎儿感染的儿童的母亲进行研究， 先天性CMV感染，采用病例对照设计，和 通过对性活跃青少年的纵向研究。