SOURCES OF MATERNAL AND FETAL CMV INFECTION

这一提议将检验一个假设，即幼儿是一个 是母亲感染巨细胞病毒的重要来源， 孕妇从孩子那里获得的母体感染 会导致胎儿感染 我们在CMV领域的广泛工作 流行病学，特别是最近对CMV传播的研究 在孩子和他们的父母中， 事实上对母体CMV的来源一无所知 感染，导致制定这一假设和我们的计划， 认识到现有的流行病学数据， 支持性传播的作用，我们还计划评估 这一机制的潜在重要性， 胎儿感染通过一项研究的母亲的儿童 先天性CMV感染，采用病例对照设计，和 通过对性活跃青少年的纵向研究。

This proposal will test the hypothesis that young children are an important source of CMV infection for their mothers and that maternal infection acquired from a child by a pregnant women can result in fetal infection. Our extensive work in CMV epidemiology, particularly recent studies of transmission of CMV among children and to their parents, coupled with knowledge that virtually nothing is known about sources of maternal CMV infection , led to formulation of this hypothesis and our plan for addressing it. Recognizing existing epidemiologic data that supports a role for sexual transmission, we also plan to evaluate the potential importance of this mechanism of maternal and fetal infection through a study of mothers of children with congenital CMV infection, utilizing a case-control design, and through longitudinal study of sexually active adolescents.