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CELLULAR IMMUNE RESPONSES TO CMV IN COGNEITAL AND PERINATAL INFECTIONS

CELLULAR IMMUNE RESPONSES TO CMV IN COGNEITAL AND PERINATAL INFECTIONS
认知和围产期感染中 CMV 的细胞免疫反应
批准号：
3857357
负责人：
ROBERT F PASS
金额：
$0.0万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3857357
关键词：
Herpesviridae disease cell mediated cytotoxicity cellular immunity congenital infection cytomegalovirus enzyme linked immunosorbent assay female flow cytometry helper T lymphocyte human pregnant subject human subject humoral immunity immunofluorescence technique immunosuppression interferons interleukin 1 interleukin 2 leukocyte activation /transformation longitudinal human study lymphocyte microorganism culture microorganism immunology monoclonal antibody newborn human (0-6 weeks) nucleic acid hybridization nucleic acid probes perinatal pregnancy immunology pregnancy infection puerperal infection radioimmunoassay serology /serodiagnosis suppressor T lymphocyte tissue /cell culture virus antigen virus cytopathogenic effect virus infection mechanism

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中文摘要
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英文摘要
The purpose of this project is to further define through longitudinal study of human subjects the specific cellular immune responses of patients with congenital CMV infection and of young women during pregnancy and the postpartum period. In the former group we will examine the hypothesis that alterations of specific cellular immunity are associated with both the persistence of infection and occurrence of progressive deterioration. In the latter group (mothers) we will determine whether specific cell mediated immunity as measured by antigen stimulated lymphokine production and CMV specific responder cell frequency is a significant determinant of virus excretion during pregnancy and the postpartum interval or of transmission of CMV to offspring.
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ADOLESCENT PREGNANCY AND CONGENITAL CYTOMEGALOVIRUS INFECTION
ADOLESCENT PREGNANCY AND CONGENITAL CYTOMEGALOVIRUS INFECTION
ACYCLOVIR VS VIDARABINE IN NEONATAL HERPES SIMPLEX INFECTION
CELLULAR IMMUNE RESPONSES TO CMV IN COGNEITAL AND PERINATAL INFECTIONS
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