CELLULAR IMMUNE RESPONSES TO CMV IN COGNEITAL AND PERINATAL INFECTIONS

认知和围产期感染中 CMV 的细胞免疫反应

• 批准号: 3878395
• 负责人: ROBERT F PASS
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3878395
• 关键词: Betaherpesvirinae; Herpesviridae disease; cell mediated cytotoxicity; cellular immunity; congenital infection; enzyme linked immunosorbent assay; flow cytometry; helper T lymphocyte; human pregnant subject; human subject; humoral immunity; immunofluorescence technique; immunosuppression; interferons; interleukin 1; interleukin 2; leukocyte activation /transformation; longitudinal human study; lymphocyte; microorganism culture; microorganism immunology; monoclonal antibody; newborn human (0-6 weeks); nucleic acid hybridization; nucleic acid probes; perinatal; pregnancy immunology; pregnancy infection; puerperal infection; radioimmunoassay; serology /serodiagnosis; suppressor T lymphocyte; tissue /cell culture; virus antigen; virus cytopathogenic effect; virus infection mechanism

The purpose of this project is to further define through longitudinal study of human subjects the specific cellular immune responses of patients with congenital CMV infection and of young women during pregnancy and the postpartum period. In the former group we will examine the hypothesis that alterations of specific cellular immunity are associated with both the persistence of infection and occurrence of progressive deterioration. In the latter group (mothers) we will determine whether specific cell mediated immunity as measured by antigen stimulated lymphokine production and CMV specific responder cell frequency is a significant determinant of virus excretion during pregnancy and the postpartum interval or of transmission of CMV to offspring.

该项目的目的是通过进一步定义 人类受试者的纵向研究， 先天性CMV感染患者的免疫应答， 年轻妇女在怀孕和产后期间。 在 对于前一组，我们将研究改变 特异性细胞免疫与 持续感染和进行性 恶化 在后一组（母亲）中，我们将确定 通过抗原测定的特异性细胞介导的免疫力 刺激淋巴因子产生和CMV特异性应答 细胞频率是病毒排泄的重要决定因素 在怀孕和产后期间或传播期间 CMV感染后代。